7-Bromo-3,4-dihydro-1H-quinolin-2-one(CAS#14548-51-7)

Introduction

7-Bromo-3,4-dihydroquinoline-2(1H)-one is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: 7-Bromo-3,4-dihydroquinoline-2(1H)-one is a white to light yellow solid.- Solubility: It is soluble in common organic solvents such as ethanol, ether and methylene chloride.- Stability: Relatively stable under conventional storage and use conditions.Use:- 7-Bromo-3,4-dihydroquinoline-2(1H)-one is generally used as a reagent in organic synthesis, and is often used in the synthesis of compounds with quinoline structure.Method:- The preparation of 7-bromo-3,4-dihydroquinoline-2(1H)-one can be achieved by several methods, one of which is commonly used by introducing bromine atoms into quinoline. Compounds of interest can be obtained by adding brominated reagents such as bromine or nitrosoammonium bromide to the quinoline reaction.Safety Information:- Avoid inhalation or contact with skin and eyes.- Make sure there is adequate ventilation when in use.- Appropriate personal protective equipment such as lab gloves, face shields, and goggles should be worn.- Avoid ignition and combustibles when handling and storing.

Application
7-Bromo-3,4-dihydro-1H-quinolin-2-one (CAS 14548-51-7) is a functionalized quinolinone derivative widely used as a key intermediate in medicinal chemistry and drug discovery. The bromine at the 7-position enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) for rapid diversification in structure-activity relationship (SAR) studies. The 3,4-dihydro-2-one core provides a rigid, planar scaffold with hydrogen bond donor/acceptor sites, enhancing target binding affinity. This building block is extensively employed in the synthesis of potent kinase inhibitors targeting cancer, inflammation, and neurological disorders. It also serves as a precursor for antiviral, antimicrobial, and anti-inflammatory agents. Its high purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this pharmaceutical intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.