COH29(CAS#1190932-38-7)

Introduction

COH29 is a chemical compound. The following is an introduction to the nature, use, preparation method and safety information of COH29:Quality:- COH29 is an organic compound that has a solid form.- It has a certain solubility and is soluble in organic solvents.Use:- Its structure gives it the ability to interact with cancer cells, thus inhibiting their growth and spread.Method:- COH29 can be prepared in a variety of ways, and a common method is to synthesize it by synthesizing organic synthetic chemical reactions.- The specific preparation method depends on the raw materials used and the reaction conditions, and usually requires organic synthesis laboratory equipment and technology.Safety Information:- COH29 has not been reported to have significant toxicity under normal use conditions.- However, as an organic compound, it is necessary to strictly adhere to the safe practices of chemical laboratories.- When handling COH29, wear appropriate personal protective equipment such as lab gloves and protective glasses and avoid direct contact with the skin and eyes.- If necessary, consult the relevant Safety Data Sheets and operating instructions to ensure safe operation.

Application
COH29 (CAS 1190932-38-7) is a novel, orally bioavailable, aromatically substituted thiazole compound that functions as a potent small molecule inhibitor of human ribonucleotide reductase (RNR), the rate-limiting enzyme in de novo DNA synthesis. It exhibits a unique mechanism of action by binding to the RNR M2 subunit (hRRM2), thereby blocking holoenzyme formation to inhibit cancer cell proliferation. COH29 is reported to overcome resistance to conventional RNR inhibitors such as hydroxyurea and gemcitabine, and demonstrates notable antitumor activity across the NCI 60 human cancer cell line panel, particularly against hard-to-treat ovarian cancer, leukemia, and breast cancer, while showing little cytotoxicity to normal fibroblasts or endothelial cells. As a valuable pharmaceutical intermediate and reference standard, COH29 is widely utilized in oncology research, DNA damage response studies, and preclinical cancer drug evaluation, including its ongoing investigation in phase I clinical trials for patients with advanced solid tumors refractory to standard therapy. Xinchem offers flexible custom synthesis, custom chemical synthesis, and reliable contract manufacturing of high-purity COH29 with full analytical support (HPLC, MS, NMR), scaled from R&D grams to commercial kilograms. Contact us today for a competitive quote and reliable global supply.