(-)-Corey lactone diol(CAS#32233-40-2)

Introduction

Corinolide glycol (also known as 1,2-hexanediol) is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of Colinolide glycol:- Colinolide glycol is a colorless to yellowish liquid with a sweet taste. - It is a relatively stable compound that is not easily oxidized by air. Uses:- Colinolide glycol is mainly used as a solvent, lubricant and plasticizer. - In addition, Colinate glycol can also be used in the preparation of compounds such as polyester resins, ester surfactants and polyethers. Preparation method:- Colinolide glycol can be prepared by the reaction of 1,2-hexanedibromoether and sodium hydroxide. First, 1,2-hexanedibromoether is reacted with sodium hydroxide to generate the corresponding sodium salt. This sodium salt is then reacted with water and further hydrolyzed to form corianolide glycol. Safety Information:- Corianolide glycol is generally safe under proper use and storage conditions. - In case of contact with skin and eyes, rinse immediately with plenty of water. - During use, avoid inhaling aerosols and vapors, and leave the work area in time if there is any abnormal reaction. - Take fire precautions when using near potential sources of fire. - Proper handling and safety measures for storage must be followed, and waste needs to be disposed of in accordance with the relevant regulations. If necessary, consult the Safety Data Sheet or consult a professional for detailed safety information.

Application
(-)-Corey lactone diol is a chiral bicyclic γ‑lactone that serves as the pivotal building block for the stereocontrolled synthesis of natural prostaglandins and their analogs. As a premium pharmaceutical intermediate, it enables access to blockbuster APIs including the antiglaucoma agents Latanoprost and Bimatoprost, the prostacyclin analogue Beraprost for pulmonary arterial hypertension, and the synthetic PGI2 analogue Iloprost. Its reduced diol oxidation state features orthogonal primary and secondary alcohols, offering regioselective access to ω‑chain modifications without protecting‑group manipulations. Consistent enantiopurity ensures the correct stereochemistry for prostanoid receptor binding, mitigating the risk of inactive isomers. Xinchem supplies high‑purity (-)-Corey lactone diol with flexible custom synthesis and contract manufacturing, scaling reliably from R&D to commercial tons. Contact us for a competitive quote and global supply.