FMOC-D-Lys(BOC)-OH（CAS# 92122-45-7)
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29225090 |
Introduction
N(ε)-Boc-N(α)-three-dimensional lysine (Fmoc-D-Lys(Boc)-OH) is an amino acid derivative comprising a protected lysine molecule and a Fmoc group. Here are some details about this compound:
Nature:
-Chemical formula: C24H29N3O6
-Molecular weight: 455.50g/mol
-Appearance: White crystal or crystalline powder
-freezing point: about 120-126°C
-Solubility: Soluble in some organic solvents, such as dimethylthiourea (DMF), dimethylformamide (DMF) and a small amount of ethanol
Use:
- Fmoc-D-Lys(Boc)-OH is one of the commonly used amino acid protecting groups in solid phase synthesis, which can be used as a starting material for the synthesis of polypeptides and proteins
-It is widely used in pharmaceutical research, biochemistry and protein synthesis
Method:
-The preparation of Fmoc-D-Lys(Boc)-OH is usually carried out by chemical synthesis methods under the guidance of nuclear magnetic resonance. This method involves Fmoc protection of Lys(Boc)-OH and is typically carried out under basic conditions. The final product is obtained by crystallization or purification.
Safety Information:
- Fmoc-D-Lys(Boc)-OH is relatively stable under general conditions of use. However, since it is a chemical, it is still necessary to pay attention to safe operation measures.
-Avoid inhalation, ingestion or contact with skin and eyes.
-Wear protective gloves, eye protection, and a suitable lab coat for use.
-Follow appropriate laboratory safety regulations and operating guidelines when handling and storing chemicals.
Application
Fmoc-D-Lys(Boc)-OH is an orthogonally protected D-lysine derivative featuring a base-labile Fmoc group on the α-amino position and an acid-labile Boc group on the ε-amino side chain. As a standard building block for Fmoc solid-phase peptide synthesis (SPPS), it enables the precise incorporation of D-lysine residues into peptide chains. The D-configuration enhances protease resistance and can improve antimicrobial potency while reducing hemolytic activity. This building block is essential for synthesizing therapeutic peptides, including ganirelix acetate used in prostate cancer treatment. Its orthogonal protection strategy allows selective deprotection during SPPS, facilitating the assembly of complex peptide sequences for drug development, bioconjugation, and protein engineering applications. With ≥98.0% HPLC purity and ≥99.5% enantiomeric purity, it ensures stereochemical integrity in custom peptide manufacturing. Xinchem offers custom synthesis and contract manufacturing of this high-purity Fmoc amino acid with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
