Isoquinoline, 3-bromo(CAS#34784-02-6)
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29334900 |
Introduction
Isoquinoline, 3-bromo-is an organic compound with the chemical formula C9H6BrN. It is a white solid with a distinctive aromatic taste.
Regarding its properties, Isoquinoline, 3-bromo-is insoluble in water at normal temperature, but soluble in organic solvents such as ethanol, toluene, etc. It has strong stability and is relatively stable in air.
Isoquinoline, 3-bromo-is an important compound with many applications in organic synthesis. It is an important intermediate for the synthesis of various drugs, dyes, pesticides and other organic compounds. For example, it can be used in the synthesis of anticancer drugs, anti-malarial drugs, anti-anxiety drugs, etc. In addition, it can also be used as a catalyst and traceability agent for organic synthesis reactions.
There are several different ways to prepare Isoquinoline, 3-bromo. A common method is to obtain Isoquinoline, 3-bromo-by reaction of 4-bromopyridine with sodium nitrite-. Another method is obtained by reacting 3-bromobenzoic acid with an amine compound.
Regarding safety information, Isoquinoline, 3-bromo-is a corrosive chemical and care should be taken to avoid contact with skin and eyes. Follow safety procedures and use appropriate protective equipment (e. g. gloves, goggles, etc.) during use. At the same time, it should be stored in a dry, well-ventilated place, and away from open flames and high temperatures. If there is an accident, should immediately take the corresponding emergency measures, and seek medical help.
Application
3-Bromoisoquinoline (CAS 34784-02-6) is a versatile halogenated heterocyclic building block widely used in medicinal chemistry and pharmaceutical research. The bromine atom at the 3-position enables efficient cross-coupling reactions such as Suzuki-Miyaura, Buchwald-Hartwig, and Sonogashira, allowing rapid introduction of diverse aryl, heteroaryl, or alkyl substituents. This scaffold serves as a key intermediate for the synthesis of potent kinase inhibitors, anticancer agents, and modulators of various biological targets including PARP, PI3K, and DNA topoisomerases. It is also utilized in the development of fluorescent probes, agrochemicals, and materials science. Its rigid isoquinoline core enhances target binding affinity and metabolic stability. High purity ensures reproducible results in high-throughput screening and structure-activity relationship (SAR) studies. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 3-bromoisoquinoline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
