6-Bromoisoquinoline(CAS#34784-05-9)
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| HS Code | 29334900 |
Introduction
6-Bromoisoquinoline is an organic compound. It is a solid, colorless to yellowish crystal. The following is an introduction to the properties, uses, preparation methods and safety information of 6-bromoisoquinoline:Quality:Appearance: Colorless to yellowish crystalline solid.Solubility: soluble in organic solvents such as alcohols, ethers and ketones, insoluble in water.Storage stability: It needs to be sealed and stored in a cool, dry place, away from fire and oxidants.Use:It contains bromine atoms in its molecule and can also be used as a catalyst or bromine source.In organic synthesis, 6-bromoisoquinoline is often used in substitution reactions, coupling reactions, etc. in organic synthesis reactions.Method:6-Bromoisoquinoline can be prepared by reacting isoquinoline with bromine. The specific preparation method can be adjusted according to the needs and experimental conditions.During the preparation process, it is necessary to pay attention to the safety and protective measures of the operating environment, and avoid inhalation, skin or contact with eyes.Safety Information:6-Bromoisoquinoline is an organic compound with certain toxicity. Appropriate protective equipment, such as laboratory gloves, goggles, and protective clothing, should be worn when used or prepared.Avoid direct contact with skin and rinse immediately with plenty of water if contact occurs.During the treatment, pay attention to a well-ventilated laboratory environment and avoid inhaling its dust or vapors.In case of accidental inhalation or ingestion, seek medical attention immediately and provide the safety data of the compound to the physician for reference.
Application
6-Bromoisoquinoline (CAS 34784-05-9) is a versatile brominated heterocyclic building block widely used in medicinal chemistry and pharmaceutical research. The bromine atom at the 6-position enables efficient cross-coupling reactions such as Suzuki-Miyaura, Buchwald-Hartwig, and Sonogashira, allowing rapid introduction of diverse aryl, heteroaryl, or alkyl substituents. This scaffold serves as a key intermediate for the synthesis of potent kinase inhibitors, anticancer agents, and modulators of various biological targets including PI3K, mTOR, and DNA topoisomerases. It is also utilized in the development of fluorescent probes, agrochemicals, and materials science. Its rigid isoquinoline core enhances target binding affinity and metabolic stability. High purity ensures reproducible results in high-throughput screening and structure-activity relationship (SAR) studies. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 6-bromoisoquinoline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
