Methyl 3-amino-4-pyridazinecarboxylate(CAS#1256633-18-7)
Introduction
3-amino pyridazine-4-carboxylic acid methyl ester, chemical name is N-(3-amino pyridazine-4-yl) carboxylic acid methyl ester, molecular formula is C7H9N5O2. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
3-Aminopyridazine-4-carboxylic acid methyl ester is a colorless to light yellow solid with special chemical structure characteristics. It is stable at room temperature and pressure and soluble in polar organic solvents such as methanol and ethanol.
Use:
3-aminopyridazine-4-carboxylic acid methyl ester has anti-cancer activity and is commonly used in the pharmaceutical field as an anti-tumor drug synthesis intermediate. It can be used to synthesize DNA methyltransferase inhibitors, nucleoside anticancer drugs and other bioactive substances.
Method:
The preparation method of 3-aminopyridazine-4-carboxylic acid methyl ester is relatively simple, and is generally prepared by introducing an ester group on the aminopyridazine molecule for esterification. Specific steps may include reacting the aminopyridazine with methyl formate under acidic conditions to produce the desired product.
Safety Information:
When using and manipulating methyl 3-aminopyridazine-4-carboxylate, the following safety precautions should be taken:
1. use should wear appropriate personal protective equipment, such as gloves and goggles, avoid direct contact with the skin and eyes.
2. in the operation should maintain a well ventilated laboratory environment, try to avoid inhalation of dust or vapor compounds.
3. chemicals should be properly stored in a closed container, away from heat and fire sources.
4. Follow the relevant operating procedures and safety guidelines when handling chemicals.
5. In case of skin contact, inhalation or ingestion, rinse immediately with water and seek medical attention.
In general, 3-aminopyridazine-4-carboxylic acid methyl ester is a compound with special chemical structure and anti-cancer activity, which is commonly used in the pharmaceutical field as a drug synthesis intermediate. Pay attention to safe operation when using, avoid direct contact and inhalation of the compound.
Application
Methyl 3-amino-4-pyridazinecarboxylate (Methyl 3-aminopyridazine-4-carboxylate) is a high-purity heterocyclic building block featuring a pyridazine core that is emerging as a privileged fragment in pharmaceutical discovery workflows. This compound serves as a key pharmaceutical intermediate for constructing inhibitors of DNA methyltransferases and nucleoside antitumor agents. As a heterocyclic pharmaceutical intermediate, its utility extends to the synthesis of protein kinase inhibitors for targeted oncology, with pyridazine derivatives demonstrating unexpected efficacy against abnormal protein kinase activities in cancer. The scaffold has been instrumental in developing novel 3-oxo-2,3-dihydropyridazine derivatives for selective inhibition of interleukin-2-inducible T-cell kinase (ITK), showing potential as a lead candidate for T-cell leukemia treatment with favorable therapeutic index. Methyl 3-aminopyridazine-4-carboxylate has also shown potential as an antimicrobial agent against bacterial strains resistant to conventional antibiotics, and preliminary research suggests antiviral effects against HIV and influenza by interfering with viral replication processes. This pyridazine building block is also utilized in the synthesis of agrochemicals and compounds targeting neurological disorders. With its dual reactive amino and methyl ester functionalities, this scaffold supports cross-coupling reactions and amide formation, enabling rapid SAR exploration for drug discovery programs. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this versatile methyl 3-amino-4-pyridazinecarboxylate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
