5-Methoxypyridazin-3(2H)-One(CAS#123696-01-5)
Introduction
5-Methoxypyridazine-3-one is an organic compound. The following is an introduction to its nature, use, preparation method and safety information:Quality:- Appearance: 5-Methoxypyridazine-3-one is a white crystalline solid.- Solubility: It has a low solubility in water but can be dissolved in organic solvents.Use:- 5-Methoxypyridazine-3-one is an important intermediate compound that can be used in the synthesis of other compounds.Method:- 5-Methoxypyridazine-3-one is usually prepared by chemical synthesis methods. A commonly used method is to introduce methoxy groups into pyridazine compounds.- Specific synthesis methods include the use of leucine or adenosine as the starting material to construct the compound of interest through a series of chemical reactions, including alkylation, oxidation, and reduction steps.Safety Information:- Information on the toxicity and harmfulness of 5-methoxypyridazine-3-one is very limited. As a chemical substance, general safety operating procedures should be followed and handled in accordance with proper laboratory implementation standards.
Application
5-Methoxypyridazin-3(2H)-one (CAS 123696-01-5) is a functionalized pyridazinone heterocycle widely used as a key building block in medicinal chemistry and pharmaceutical research. The methoxy group at the 5-position enables electronic tuning and metabolic stabilization, while the lactam NH provides hydrogen bond donor/acceptor sites for target engagement. This scaffold is extensively employed in the synthesis of selective kinase inhibitors targeting cancer (e.g., JAK, BTK, CDK), anti-inflammatory agents, and antiviral compounds. Its rigid pyridazinone core enhances binding affinity and selectivity. Derivatives also show promise as antibacterial and antifungal agents, as well as agrochemical intermediates for herbicide and fungicide development. The compound facilitates rapid structure-activity relationship (SAR) studies via cross-coupling and amide bond formation. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this versatile intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
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