N-Methyl-N-trimethylsilylacetamide(CAS#7449-74-3)

N-Methyl-N-trimethylsilylacetamide(CAS#7449-74-3)

Introduction
N-methyl-N-trimethylsilane acetylamide, also known as N-Methyl-N-trimethylsilylacetamide.

Properties: N-methyl-N-trimethylsilane acetylamine is a colorless to yellow liquid with a distinctive ammonia odor. It can be dissolved in common organic solvents at room temperature, such as alcohols, ethers and chlorinated hydrocarbons. This compound is a relatively stable compound, but it may decompose under the action of heat and oxidants.

Usage: N-methyl-N-trimethylsilane acetylamine is widely used as a reagent in organic synthesis. It can be used as a stabilizer, intermediate and precursor to catalysts. In the process of organic synthesis, it is often used in N-methylation reactions, substitution reactions, competitive reduction and other reactions.

Preparation method: N-methyl-N-trimethylsilane acetylamine can be prepared by reacting N-methyl-N-trimethylsilyl ammonia with acetic acid. Among them, N-methyl-N-trimethylsilyl ammonia can be obtained by the reaction of sodium hydrosiliconide and methylamine.

Safety information: N-methyl-N-trimethylsilane acetylamine has low toxicity, but it is still necessary to pay attention to safe operation. It can be irritating to the skin and eyes, and should be rinsed with plenty of water in case of contact. Good ventilation conditions should be maintained during use. The compound should be kept away from ignition sources and oxidizing agents.

Application
N-Methyl-N-trimethylsilylacetamide (MSTFA, CAS 7449-74-3) is a powerful trialkylsilylating agent widely used in analytical chemistry for GC and GC-MS derivatization of polar compounds containing active hydrogens, including carbohydrates, amino acids, steroids, fatty acids, and nucleosides. It converts hydroxyl, amine, thiol, and carboxyl groups into trimethylsilyl (TMS) ethers, significantly enhancing volatility and thermal stability for reliable quantification. In organic synthesis, MSTFA serves as a versatile silylating reagent for the protection of sensitive functional groups under mild conditions. It also plays a critical role in pharmaceutical R&D for stabilizing active pharmaceutical ingredients (APIs) and improving their bioavailability, as well as in environmental analysis for detecting trace pollutants in soil and water samples. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity MSTFA with flexible scaling from R&D samples to commercial tons. Contact us today for a competitive quote and reliable global supply.