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(1-methylpyrazolo[3,4-b]pyridin-5-yl)methanol(CAS#1221288-28-3)

Chemical Property:

Molecular Formula C8H9N3O
Molar Mass 163.17656
Storage Condition Room Temprature

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Introduction

{1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl}methanol is an organic compound, and its English name is (1-methylpyrazolo[3,4-b]pyridin-5-yl)methanol.Quality:- Appearance: {1-Methyl-1H-pyrazolo[3,4-b]pyridine-5-yl} methanol is a white solid.- Solubility: It is soluble in some organic solvents such as chloroform, dichloromethane, and dicarboxamide.Use:{1-Methyl-1H-pyrazolo[3,4-b]pyridin-5-yl} methanol has a variety of uses in chemical research, such as:- It can be used as a reagent in organic synthesis reactions, such as transition metal-catalyzed reactions and reduction reactions.Method:The preparation of methanol {1-methyl-1H-pyrazolo[3,4-b]pyridine-5-yl} typically requires a multi-step reaction, and one of the most common methods is:- The precursor of the target compound is obtained by synthesizing pyridine compounds and undergoing substitution reaction with amines.- Then, when the precursor of the target compound reacts with methanol, an alcohol hydroxyl substitution reaction occurs to give the final product.Safety Information:Specific toxicity and safety information for {1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl}methanol are unknown. As an organic compound, the following safety measures should be noted:- Avoid contact with skin and eyes, and avoid inhalation or ingestion.- Appropriate personal protective equipment such as gloves, safety goggles, and protective clothing should be worn during use.- It should be operated in a well-ventilated area to avoid inhaling its volatiles.- Local regulations and safety guidelines should be followed during storage and handling.

Application
(1-Methylpyrazolo[3,4-b]pyridin-5-yl)methanol (CAS 1221288-28-3, also known as PMPH) is a premium heterocyclic building block for pharmaceutical R&D and organic synthesis. As a versatile intermediate, this hydroxymethyl-functionalized pyrazolopyridine serves as a critical scaffold for developing kinase inhibitors (e.g., JAK, BTK, CDK), antiviral agents, and central nervous system (CNS) drugs. Its rigid, purine-like fused ring enhances target binding specificity and bioavailability for drug candidates. The primary alcohol group enables diverse derivatization via oxidation to aldehyde/carboxylic acid, halogenation, or Mitsunobu couplings, making it ideal for constructing focused compound libraries. Xinchem offers custom synthesis of this key intermediate with milligram to multi-kilogram scale capabilities. Our custom chemical synthesis ensures high purity (≥97%) and reliable global supply through contract manufacturing partnerships. Contact us today and unlock your next-generation drug development.


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