1,4-difluoro-2-nitrobenzene(CAS#364-74-9)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | 2810 |
| WGK Germany | 3 |
| RTECS | CZ5715000 |
| HS Code | 29049090 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
Introduction
2,5-difluoronitrobenzene, also known as 2,5-difluoronitrobenzene, is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- 2,5-Difluoronitrobenzene is a colorless or light yellow solid.-- The compound has a weakly strong aromatic odor.- At room temperature, it undergoes a slow oxidation reaction in contact with air.Use:- 2,5-difluoronitrobenzene can be used in the field of organic synthesis.- It can also be used as an intermediate in dyes, pigments and plastic additives.Method:- The preparation of 2,5-difluoronitrobenzene is usually carried out by a nitrolation reaction.- A common method is to react 2,5-difluorochlorobenzene and silver nitrite in the presence of sulfuric acid to produce 2,5-difluoronitrobenzene.Safety Information:- 2,5-Difluoronitrobenzene is a hazardous substance and care should be taken to avoid contact and inhalation.- When operating, appropriate protective measures should be taken, such as wearing gloves, protective glasses and work clothes.- In case of contact with skin or eyes, rinse immediately with plenty of water.The above is an introduction to the properties, uses, preparation methods and safety information of 2,5-difluoronitrobenzene.
Application
1,4-Difluoro-2-nitrobenzene is a high-purity, multifunctional aromatic intermediate serving as a critical building block in pharmaceuticals, agrochemicals, and advanced materials. As a key fluorinated pharmaceutical intermediate, it is employed in the synthesis of antidepressant APIs including fluoxetine, and atypical antipsychotics such as olanzapine and risperidone. In crop protection, this versatile agrochemical intermediate is used to construct high-value herbicides (diflufenican, flufenacet) and the broad-spectrum insecticide fipronil. Its unique 2,5-difluoro substitution pattern enables regioselective nucleophilic aromatic substitution and palladium-catalyzed cross-coupling reactions for rapid drug discovery library construction. This intermediate also serves as a precursor for specialty dyes, pigments, and plastic additives, and as a valuable building block for fluorinated liquid crystals used in display materials. High purity ensures reproducible results in custom chemical synthesis, kilo-scale process development, and cGMP manufacturing. Xinchem is a premier manufacturer and supplier of 1,4-difluoro-2-nitrobenzene. We offer flexible custom synthesis and reliable contract manufacturing with reliable global supply, scaled from R&D research grams to commercial metric tons. Contact us today for a competitive quote.
