2-Bromo-1-(5-Chloro-Thiophen-2-Yl)-Ethanone(CAS#57731-17-6)
Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| Hazard Note | Corrosive/Lachrymatory/Keep Cold |
| Hazard Class | IRRITANT |
2-Bromo-1-(5-Chloro-Thiophen-2-Yl)-Ethanone(CAS#57731-17-6) introduction
The properties of this compound are as follows:
- Appearance: White to pale yellow solid
- Solubility: Slightly soluble in water, soluble in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol
2-Bromo-1-(5-chlorothiophene-2-yl)acetophenone is commonly used in some reactions and reagents in organic synthesis:
- Used as a reagent in organic synthesis and can be used to construct the backbone of complex organic molecules
- Used in the synthesis reaction of thiophene derivatives
The method for preparing 2-bromo-1-(5-chlorothiophene-2-yl)ethyl ketone is as follows:
2-Bromo-1-(5-chlorothiophene-2-yl)acetophenone can be obtained by reacting 5-chlorothiophene-2-carboxylate with bromoethyl ketone.
Safety Information: 2-Bromo-1-(5-chlorothiophene-2-yl)acetone is generally safe to handle under the conditions of correct use and storage. However, there are still the following aspects to be aware of:
- Contact skin and eyes: May be irritating to the skin and eyes, direct contact should be avoided. In case of contact, the affected area should be immediately rinsed with plenty of water.
- Inhalation and ingestion: May be irritating to the respiratory and digestive tract and should be avoided. Ensure good ventilation during operation and pay attention to personal protective measures.
- Toxicity: Specific toxicity data are limited, but depending on the structure of the compound, it may have some toxicity. Appropriate personal protective equipment should be used, such as wearing protective gloves and eye/face protection.
Application
2-Bromo-1-(5-chlorothiophen-2-yl)ethanone (CAS 57731-17-6) is a functionalized heteroaryl α-bromoketone that serves as a versatile intermediate in pharmaceutical and agrochemical research. The reactive α-bromoketone moiety enables nucleophilic substitution with amines, thiols, and other nucleophiles, allowing rapid construction of diverse heterocyclic scaffolds such as thiazoles, imidazoles, oxazoles, and aminothiophenes. This building block has been utilized in the synthesis of novel 2-aminothiophene-3-carboxylic acid derivatives as potent antifungal agents against Candida species. The 5-chlorothiophene ring provides additional handles for cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) and metabolic stability. In drug discovery, this intermediate is employed to generate focused libraries for screening against antimicrobial, anticancer, and anti-inflammatory targets. Its high purity ensures reproducible results in structure-activity relationship (SAR) studies, hit-to-lead optimization, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high-purity building block with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
