2-Bromo-4-Chloropheno(CAS#695-96-5)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/39 - S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 2020 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 29081000 |
| Hazard Class | IRRITANT |
Introduction
2-Bromo-4-chlorophenol is an organic compound. The following is an introduction to some of its properties, uses, manufacturing methods and safety information: Properties:- Appearance: colorless to light yellow crystals or crystalline powders; - Solubility: Soluble in ethanol, ether and chloroform, slightly soluble in water. Uses:-2-Bromo-4-chlorophenol can be used as an antibacterial agent and fungicide, and is often used as a protective and preservative for wood; - Can be used as a catalyst in organic synthesis reactions. Method: The preparation of 2-bromo-4-chlorophenol is usually obtained by reacting 2-bromophenol and cuprous chloride under appropriate conditions in the presence of a catalyst. The specific preparation method can be optimized and adjusted as needed. Safety Information:- Avoid inhaling dust, fumes or sprays; - Wear appropriate personal protective equipment such as gloves, goggles, and respirators when using; - avoid reacting with strong oxidizing agents; - 2-Bromo-4-chlorophenol needs to be stored in a dry, cool place, away from fire and open flames.
Application
2-Bromo-4-chlorophenol (CAS 695-96-5) is a mixed dihalogenated phenol featuring an ortho-bromo and para-chloro substitution pattern, which provides a unique reactivity profile for chemoselective transformations in organic synthesis. As a versatile building block, it serves as a critical pharmaceutical intermediate in the synthesis of drug candidates such as selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists and the 5-HT3 receptor antagonist Zatosetron. In agrochemical R&D, this compound is utilized as a key precursor for the synthesis of active ingredients in insecticides, herbicides, and fungicides, and is recognized as a detoxified metabolite of the organophosphorus pesticide profenofos, making it an essential reference standard for environmental biomonitoring studies. The differential bond dissociation energies of the C–Br and C–Cl bonds enable exclusive Suzuki–Miyaura cross-coupling at the ortho-bromine position while preserving the para-chlorine for downstream modifications, critical for constructing complex heterocyclic scaffolds and drug-like libraries. Beyond pharmaceutical and agrochemical applications, 2-bromo-4-chlorophenol functions as an antibacterial agent, wood preservative, and catalyst in organic synthesis. It is also employed as a model compound in photochemical studies, disinfection byproduct research, and degradation studies of persistent halogenated aromatic pollutants. Its high purity and versatile reactivity support GMP manufacturing, SAR studies, and high-throughput screening across medicinal chemistry, materials science, and environmental analysis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2-bromo-4-chlorophenol (CAS 695-96-5) with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
