2-Chloro-5-quinolinecarboxylic acid(CAS#1092287-30-3)
Introduction
2-Chloroquinoline-5-carboxylic acid, also known as, acid, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
2-Chloroquinoline-5-carboxylic acid is a white solid with a special chemical structure. Its chemical formula is C10H6ClNO2 and its molecular weight is 215.61. Its melting point is about 180-185°C.
Use:
2-chloroquinoline-5-carboxylic acid has important applications in the field of medicine. It is one of the precursor compounds of the anti-malaria drug malaria. It also has potential anticancer and antiviral activities and has been used as a reagent and ligand in related studies.
Preparation Method:
There are many methods for preparing 2-chloroquinoline-5-carboxylic acid, the common ones include:
1.2-chloroquinoline -5-carboxylic acid is generated by acidic hydrolysis of 2-chloroquinoline;
2. 2-Chloroquinoline-5-carboxylic acid is synthesized by reaction steps such as oxidation and carboxylation of 2-chloroquinoline.
Safety Information:
2-chloroquinoline -5-carboxylic acid in the use and handling process should pay attention to safety measures. It may cause irritation and damage to the human body, so direct contact with the skin, eyes and respiratory tract should be avoided. Personal protective equipment, such as laboratory gloves, goggles and protective masks, should be worn during operation. In addition, the compound should be stored and handled properly to avoid adverse reactions or accidents with other chemicals. In the event of an accident, seek medical attention immediately and provide relevant chemical composition information.
Application
2-Chloro-5-quinolinecarboxylic acid (CAS 1092287-30-3) is a key pharmaceutical intermediate featuring both a chlorine atom and a carboxylic acid group on the quinoline core. It serves as a precursor for antimalarial drugs, including the synthesis of advanced quinoline-based therapeutics targeting Plasmodium falciparum. This versatile compound also exhibits potential anticancer, antiviral, antibacterial, and antifungal activities, making it valuable in drug discovery programs. Ongoing research explores its role as an inhibitor of EGFR-TK and other tyrosine kinases, offering promise for targeted cancer therapies. Additionally, it functions as a reagent and ligand in coordination chemistry and organic synthesis, enabling the construction of diverse heterocyclic libraries for structure-activity relationship (SAR) studies. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2-Chloro-5-quinolinecarboxylic acid with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.







