2-Fluoro-2′-Bromobiphenyl(CAS#1554-05-8)

 2-Fluoro-2'-Bromobiphenyl(CAS#1554-05-8),physical properties

Appearance: Usually white crystals or powdery solids.
Melting point: 39-41 ℃.
Boiling point: 338.9 ° C (at 760 mmHg pressure).
Density: 1.464 g/cm ³.
Refractive index: 1.478.
chemical properties
Solubility: Insoluble in water, but has a certain degree of solubility in organic solvents.
Stability: Relatively stable under conventional storage conditions and not easily decomposed.
Chemical reactions: can participate in various chemical reactions as important intermediates, such as electrophilic substitution reactions with nucleophilic reagents.
Safety Information
Danger: Irritable, harmful, and harmful to the environment.
Safe operation: Proper personal protective equipment should be worn during operation to avoid inhaling its vapors or dust, and to ensure that the operation is carried out in a well ventilated area.
Storage conditions: It should be stored in a sealed container, away from sources of fire and oxidants.
application
This compound is mainly used in organic synthesis, especially as an intermediate in fields such as medicine and pesticides.

Application
2-Fluoro-2'-bromobiphenyl (CAS 1554-05-8) is a halogenated biphenyl derivative widely used as a versatile intermediate in pharmaceutical, agrochemical, and materials science research. The ortho-fluorine and ortho-bromine substitution pattern enables selective functionalization via cross-coupling reactions such as Suzuki-Miyaura, Stille, and Buchwald-Hartwig couplings. It serves as a key building block for the synthesis of liquid crystals, organic light-emitting diodes (OLEDs), and conjugated polymers due to its rigid biphenyl core and electronic tuning capabilities. In medicinal chemistry, it is employed in the development of non-steroidal anti-inflammatory drugs (NSAIDs), antifungal agents, and kinase inhibitors. The bromine atom allows for further arylation or heteroarylation, while the fluorine atom improves metabolic stability and membrane permeability. High-purity 2-fluoro-2'-bromobiphenyl ensures reproducible yields in complex synthetic routes. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this specialty biphenyl with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.