2-Propargyloxane(CAS#6089-04-9)
Risk and Safety
| Risk Codes | 11 - Highly Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S16 - Keep away from sources of ignition. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| HS Code | 29329900 |
| Hazard Class | 3.2 |
| Packing Group | III |
2-Propargyloxane(CAS#6089-04-9) introduction
2-(2-propropoxy)tetrahydropyran. The following is an introduction to the properties, uses, preparation methods, and safety information of the compound:
Quality:
Appearance: Colorless liquid.
Density: 0.887 g/cm³.
Solubility: Soluble in water, alcohol and ether solvents.
Use:
It is also commonly used as a solvent in the polymer industry, e.g. in the preparation of polyacrylamide (PAN) fibers.
Method:
THF can be prepared by the condensation reaction of 1,4-butanediol. 1,4-butanediol is reacted with dilute sulfuric acid or an acidic catalyst to generate 1,4-butadiene; Then, it reacts with acetylene to form 2-(2-propropoxy)tetrahydropyran.
It can also be prepared by the reaction of tetrahydropyran with dimethyl carbonate in the presence of sodium hydroxide.
Safety Information:
May be irritating to the skin and eyes, use personal protective equipment such as gloves and goggles.
It should be stored in a cool, dry place, away from fire and oxidants.
Pay attention to a well-ventilated environment when using it to prevent steam inhalation and cause uncomfortable symptoms.
Application
2-Propargyloxane is a high-purity (>99%) organic liquid extensively utilized as a versatile PROTAC linker building block and synthetic organic intermediate. In pharmaceutical R&D, it serves as a key raw material in the synthesis of PROTAC (proteolysis-targeting chimera) molecules for targeted protein degradation. As a synthetic intermediate, it is employed as a reagent in the total synthesis of complex natural products, including the spiropiperidine toxin (-)-Histrionicotoxin and the fertilization inhibitor (-)-Exiguolide. Beyond drug discovery, this compound is used as an acidic solvent in the polymer industry (e.g., polyacrylamide preparation) and in specialty coatings and adhesives, where it enhances adhesion and environmental resistance. It also finds application in flavor and fragrance creation, as well as in the formulation of agrochemicals to improve the efficacy of crop protection products. Xinchem offers flexible custom synthesis and contract manufacturing of high-purity 2-Propargyloxane, scaled reliably from R&D to commercial tons. Contact us for a competitive quote.
