2,4-Dichloro-5-aminopyrimidine(CAS#5177-27-5)

Application
2,4-Dichloro-5-aminopyrimidine (CAS 5177-27-5) is a versatile heterocyclic intermediate featuring an amino group at the 5-position and two reactive chlorines at the 2- and 4-positions. This substitution pattern enables sequential nucleophilic aromatic substitution and palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira), allowing rapid construction of diverse 2,4,5-trisubstituted pyrimidine libraries. As a key pharmaceutical intermediate, it is widely used in medicinal chemistry for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases, including JAK, BTK, CDK, and EGFR inhibitors. The amino group facilitates amide, urea, or sulfonamide formation, while the chlorines enable orthogonal functionalization. This scaffold also serves as a precursor for antiviral agents (e.g., HIV integrase inhibitors), antibacterial compounds, and agrochemicals (herbicides, fungicides). Its high purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high-purity intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.