3-Chloro-6-iodopyridazine(CAS#135034-10-5)
| Hazard Class | IRRITANT |
Introduction
3-Chloro-6-iodopyridazine is an organic compound with the chemical formula C5H2ClIN2. The following is a description of its nature, use, preparation and safety information:
Nature:
1. Appearance: 3-Chloro-6-iodopyridazine is a white crystalline solid.
2. Solubility: It is almost insoluble in water, but can be dissolved in organic solvents (such as ethanol, acetone, benzene, etc.).
Use:
1. Chemical research: 3-chloro-6-iodopyridazine, as an important organic synthesis intermediate, is widely used in organic synthesis reactions, such as catalyst, zinc-iodine exchange reaction, etc.
2. Drug research: It is also used in drug research and can be used as a precursor for synthetic drugs.
Preparation Method:
3-chloro-6-iodopyridazine is generally prepared by reacting 2-nitro-5-phosgene pyridazine with sodium nitrite, followed by chlorination and iodination. The specific synthesis method needs to be carried out under laboratory conditions.
Safety Information:
1. 3-Chloro-6-iodopyridazine should be kept away from fire sources and oxidizing agents.
2. When in contact with skin, eyes or by taking, rinse immediately with plenty of water for at least 15 minutes and seek medical help.
3. When using and storing, please follow all safe operating procedures and ensure that the operation is carried out in a well-ventilated area.
4. Follow local national laws and regulations and laboratory operating guidelines to properly handle and dispose of waste and chemicals.
Application
3-Chloro-6-iodopyridazine (CAS 135034-10-5) is a dihalogenated heterocyclic building block featuring orthogonal chlorine and iodine leaving groups. The iodine at the 6-position enables highly selective palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Stille, Sonogashira, Buchwald-Hartwig) due to its superior oxidative addition rate, while the chlorine at the 3-position can be sequentially functionalized via nucleophilic aromatic substitution or higher-temperature cross-couplings. This scaffold is widely used in medicinal chemistry for the rapid construction of diverse pyridazine-based libraries targeting kinases (JAK, BTK, CDK), antiviral agents, and anti-inflammatory compounds. Its derivatives also show promise as agrochemicals (herbicides, fungicides) and fluorescent probes. The orthogonal reactivity enables efficient SAR exploration and late-stage diversification. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this versatile intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.


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