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3-oxo-3,4-dihydropyrazine-2-carboxylic acid(CAS#20737-42-2)

Chemical Property:

Molecular Formula C5H4N2O3
Molar Mass 140.1
Density 1.63±0.1 g/cm3(Predicted)
Melting Point 218-220 °C
Boling Point 608.5°C at 760 mmHg
Flash Point 321.8°C
Vapor Presure 1.17E-15mmHg at 25°C
Appearance Solid
pKa 12.72±0.20(Predicted)
Storage Condition 2-8°C
Refractive Index 1.662
MDL MFCD00235136

Product Detail

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Introduction

3-oxo-3 is an organic compound with the chemical formula C6H7N3O3. The following is a description of its nature, use, preparation and safety information:

 

Nature:

-Appearance: 3-oxo-3, acid is a colorless crystalline solid.

-Solubility: It can be dissolved in water and is stable under acidic conditions.

-Melting point: 3-oxo-3, the melting point of acid is about 190 ° C.

 

Use:

-Pharmaceutical field: It is widely used as an intermediate in drug synthesis, especially for the synthesis of antiepileptic drugs.

-Chemical research: 3-oxo-3, acid can also be used as a reagent in organic synthesis.

 

Method:

- 3-oxo-3, the preparation of acid can be achieved by the acid-catalyzed hydroxymethylation reaction of pyrazine formic acid. A common method is to use methanol as the solvent and heat the reaction under acidic conditions. After the reaction, the target product was purified by distillation and crystallization.

 

Safety Information:

- 3-oxo-3, acid has no obvious toxicity and harm to human body and environment under regular use conditions.

-However, as an organic matter, it should be stored in a dry, well-ventilated place, and away from fire and oxidants.

-When using, wear appropriate personal protective equipment, such as laboratory gloves and goggles, and avoid contact with skin and eyes.

 

Please note that this is only a brief introduction to the common Properties, Uses, methods, and safety information of 3-oxo-3 acid. For more detailed information and experimental instructions in a specific application or study, please refer to the relevant literature or consult a professional.

Application
3-Oxo-3,4-dihydropyrazine-2-carboxylic acid (CAS 20737-42-2) is a valuable heterocyclic building block used in medicinal chemistry and pharmaceutical research. Its pyrazinone core with a carboxylic acid group enables diverse functionalization, including amidation, esterification, and decarboxylative coupling. This intermediate is key for synthesizing bioactive molecules such as enzyme inhibitors (e.g., metalloproteinase and kinase modulators), antiviral agents, and antibacterial compounds. The rigid, planar structure enhances target binding affinity and metabolic stability. It also serves as a precursor for peptide mimetics and heterocyclic drug libraries. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this compound with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.


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