6-BROMOPYRAZIN-2-AMINE(CAS#54237-53-5)
Introduction
2-Amino-6-bromopyrazine. The following is a description of its properties, uses, manufacturing methods and safety information:Quality:- Appearance: 2-Amino-6-bromopyrazine is a white crystalline solid.- Solubility: It has a low solubility in water but can be dissolved in some organic solvents such as ethanol and dimethyl sulfoxide.Use:- Chemical synthesis: 2-amino-6-bromopyrazine can be used as a starting material in organic synthesis and can be used to synthesize various organic compounds.Method:The preparation of 2-amino-6-bromopyrazine can be carried out by the following steps:2,6-dichloropyrazine is reacted with ammonia water to produce 2-amino-6-chloropyrazine.2-amino-6-chloropyrazine is reacted with silver sulfate to displace chlorine atoms to produce 2-amino-6-bromopyrazine.Safety Information:- 2-Amino-6-bromopyrazine is harmful to human health, and contact with human skin, eyes, or inhalation of its powder may cause irritation and damage.- Personal protective equipment (PPE) including protective eyewear, chemical protective clothing and gloves should be worn when in use.- Keep away from fire and oxidizers when storing, and keep tightly sealed.- Comply with safe operating procedures when using and disposing of, and dispose of waste in accordance with local regulations.
Application
6-Bromopyrazin-2-amine (CAS 54237-53-5) is a versatile heterocyclic building block widely used in medicinal chemistry and drug discovery. The bromine atom at the 6-position enables efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) for introducing diverse aryl, heteroaryl, or alkyl substituents, while the primary amine at the 2-position allows amide, urea, or sulfonamide formation. This scaffold is a key intermediate for synthesizing kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK inhibitors). It also serves as a precursor for antiviral, antibacterial, and antifungal agents. Its pyrazine core enhances metabolic stability and target binding affinity, facilitating rapid structure-activity relationship (SAR) studies. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 6-bromopyrazin-2-amine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
