3,4-difluorobenzyl alcohol(CAS#85118-05-4)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29062990 |
| Hazard Class | IRRITANT |
Introduction
3,4-Difluorobenzyl alcohol is a common organic compound.Quality:- Appearance: 3,4-Difluorobenzyl alcohol is a white crystal or crystalline powder.- Solubility: 3,4-difluorobenzyl alcohol is less soluble in water and soluble in organic solvents such as ethers, alcohols and ketones.Use:- In chemical research, 3,4-difluorobenzyl alcohol can also be used as an introducer for fluorine atoms.Method:- 3,4-difluorobenzyl alcohol can be prepared by fluorination of benzyl alcohol. The specific step is to react benzyl alcohol with a fluorinating agent (such as hydrofluoride or indium trifluoride, etc.) and carry out it in an appropriate solvent, and the product can be purified to obtain 3,4-difluorobenzyl alcohol.Safety Information:- 3,4-Difluorobenzyl alcohol is an organic compound with certain toxicity.- When handling 3,4-difluorobenzyl alcohol, take the necessary safety measures, such as wearing chemical gloves, goggles, and protective clothing.
Application
3,4-Difluorobenzyl alcohol is a high-purity fluorinated building block widely used as a key intermediate in pharmaceutical, agrochemical, and material science research. The strategic introduction of two fluorine atoms enhances metabolic stability, lipophilicity, and bioavailability of drug candidates. This compound serves as a versatile precursor for the synthesis of CNS-active agents (antidepressants, antipsychotics), kinase inhibitors, and anti-inflammatory APIs. In agrochemical development, it is utilized to prepare selective herbicides, fungicides, and insecticides with improved target selectivity and environmental safety. The primary alcohol group allows facile oxidation to the corresponding aldehyde or carboxylic acid, as well as esterification and ether formation, enabling rapid structure-activity relationship (SAR) studies. Additionally, it is employed in the production of liquid crystal display materials, specialty polymers, and fluorinated fine chemicals. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of 3,4-difluorobenzyl alcohol with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and dependable global supply.
