4-Bromo-1-chloroisoquinoline(CAS#66728-98-1)

Introduction

4-Bromo-1-chloroisoquinoline is an organic compound. The following is an introduction to its nature, use, manufacturing method and safety information:Quality:4-Bromo-1-chloroisoquinoline is a solid compound that is generally white to slightly yellow crystals.Use:4-Bromo-1-chloroisoquinoline can be used as an important intermediate in organic synthesis.Method:The preparation of 4-bromo-1-chloroisoquinoline generally uses the method of chemical synthesis. A common method is obtained by the reaction of isoquinoline chloride and ammonium bromide in an organic solvent.Safety Information:Appropriate safety measures need to be taken when using or handling 4-bromo-1-chloroisoquinoline. It can be irritating to the skin, eyes, and respiratory system and should be avoided. When operating, appropriate protective equipment such as chemical protective gloves and goggles should be worn. It should be operated in a well-ventilated area to avoid inhaling its volatiles.

Application
4-Bromo-1-chloroisoquinoline (CAS 66728-98-1) is a high-purity dihalogenated heterocyclic building block widely used in medicinal chemistry and drug discovery. The orthogonal leaving groups at the 4-position (bromo) and 1-position (chloro) enable sequential, site-selective palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Buchwald-Hartwig, and Sonogashira, as well as nucleophilic aromatic substitutions. This allows rapid construction of diverse polysubstituted isoquinoline libraries for structure-activity relationship (SAR) studies. This scaffold serves as a key intermediate for the synthesis of potent kinase inhibitors targeting cancer (e.g., PI3K, mTOR, DNA topoisomerases), inflammation, and neurological disorders. It is also utilized in developing antiviral, antimicrobial, and anti-inflammatory agents, as well as fluorescent probes for bioimaging and agrochemicals. Its rigid, planar isoquinoline core enhances target binding affinity and metabolic stability. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 4-bromo-1-chloroisoquinoline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.