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4(1H)-Pyrimidinone, 2-chloro- (9CI)(CAS#55873-09-1)

Chemical Property:

Molecular Formula C4H3ClN2O
Molar Mass 130.53
Density 1.55±0.1 g/cm3(Predicted)
pKa 6.37±0.40(Predicted)
Storage Condition Inert atmosphere,Store in freezer, under -20°C

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Introduction

2-Chloro-4-hydroxypyrimidinone (4(1H)-Pyrimidinone, 2-chloro- (9CI)) is an organic compound that contains 2-chloroyl and 4-hydroxypyrimidine groups in its chemical structure. The following is a presentation on the properties, uses, preparation methods, and safety information of this compound:Properties: 2-Chloro-4-hydroxypyrimidine is a colorless crystal or white crystalline powder. It is stable at room temperature and has low solubility in water. It can be dissolved in many organic solvents such as alcohols, ketones, and esters.Uses: 2-Chloro-4-hydroxypyrimidine has a variety of applications in organic synthesis. It can be used as an intermediate in the synthesis of oxalate reductase inhibitors. It can also be used to synthesize organic chemicals such as pyrimidines, oxalate reductase inhibitors, etc.Preparation method: There are various preparation methods of 2-chloro-4-hydroxypyrimidine. A common method is to synthesize 2-chloropyrimidine and hydroxylamine by reaction under suitable conditions. Specific reaction conditions and experimental procedures can be selected and optimized according to actual needs and references.Safety Information: 2-Chloro-4-hydroxypyrimidine is an organic compound that requires caution when handling and storage. It can be irritating to the eyes, skin, and respiratory system, and appropriate personal protective equipment such as glasses, gloves, and protective masks should be worn when operating. Contact with substances such as strong oxidants, strong acids, and strong bases should be avoided to prevent dangerous reactions. When using and handling this compound, please refer to appropriate safe handling guidelines and store and dispose of it in accordance with relevant regulations.

Application

2-Chloro-4(1H)-pyrimidinone (2-Chloro-4-hydroxypyrimidine, CAS 55873-09-1) is a versatile pyrimidinone building block. It is a key intermediate for constructing GSK-3β inhibitors and is also utilized as a reference standard for Pazopanib impurity profiling. The reactive chlorine at the 2-position enables efficient nucleophilic substitution to form 2-aminopyrimidines, while the 4-hydroxyl/pyrimidinone tautomer provides a handle for alkylation. Its derivatives have been studied for applications as anti-inflammatory agents and as potential antimalarial therapeutics. Xinchem offers high-purity 2-Chloro-4(1H)-pyrimidinone with reliable contract manufacturing and flexible custom synthesis to support both R&D and commercial production. Contact us today for a competitive quote and global supply.


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