7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(CAS#17680-55-6)

Introduction

7-BROMO-1,2,3, 4-tetrahydro-isoquinoline is an organic compound with the chemical formula C9H13BrN. The following is a description of its nature, use, preparation and safety information:

Nature:

7-BROMO-1,2,3, 4-tetrahydro-isoquinoline is a white crystal with characteristics of organic bromide. It is a solid, stable at room temperature, but can decompose when heated.

Use:

7-BROMO-1,2,3, 4-tetrahydro-isoquinoline has certain application value in the field of pharmacy. It can be used as an intermediate in the synthesis of other drugs, such as antihypertensive drugs and antidepressants. In addition, it can also be used as a chemical reagent and play an important role in organic synthesis.

Method:

The preparation of 7-BROMO-1,2,3, 4-tetrahydro-isoquinoline can be achieved by reacting 1,2,3,4-tetrahydroisoquinoline with bromine. Typically, bromine is used as the solvent and reactant, and heating the reaction can facilitate the reaction.

Safety Information:

When handling 7-BROMO-1,2,3, 4-tetrahydro-isoquinoline, you need to pay attention to the following safety matters:

-It is an organic bromide and may be harmful to health. Avoid direct contact with skin and eyes during operation and ensure adequate ventilation.

-During storage and handling, it should be placed away from fire and flammable materials to avoid fire and explosion.

-In the event of inadvertent inhalation, ingestion or skin contact with this compound, seek immediate medical attention and deal with it as recommended by your doctor.

Application
7-Bromo-1,2,3,4-tetrahydroisoquinoline (CAS 17680-55-6) is a functionalized tetrahydroisoquinoline (THIQ) derivative bearing a bromine atom at the 7-position. This versatile heterocyclic building block is widely used in medicinal chemistry and pharmaceutical research, particularly for the synthesis of central nervous system (CNS) agents, including potential therapeutics for Parkinson’s disease, Alzheimer’s disease, depression, and anxiety disorders. The bromine enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl substituents, facilitating rapid structure-activity relationship (SAR) studies. As a privileged scaffold in drug design, it also serves as a key intermediate for developing kinase inhibitors targeting cancer, inflammation, and neurological disorders. Its rigid, saturated THIQ core offers improved metabolic stability and blood-brain barrier penetration. Additionally, it is utilized in the synthesis of GPCR modulators, neuroprotective agents, and agrochemicals. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key pharmaceutical intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.