5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID(CAS#916325-85-4)

Introduction

5-Bromo-1H-pyrazolo[3,4-B]pyridine-3-carboxylic acid. Its properties are as follows:Appearance: 5-Bromo-1H-pyrazole[3,4-B]pyridine-3-carboxylic acid is a white to light yellow solid.Solubility: 5-bromo-1H-pyrazole[3,4-B]pyridin-3-carboxylic acid is soluble in some organic solvents, such as dimethyl sulfoxide and ethanol, but insoluble in water.Method: 5-bromo-1H-pyrazole [3,4-B]pyridine-3-carboxylic acid can be synthesized by a variety of methods. One method is to synthesize 5-bromo-1H-pyrazolo[3,4-B]pyridine, and then acidify it under alkaline conditions to form carboxylic acids.Safety information: 5-Bromo-1H-pyrazolo[3,4-B]pyridine-3-carboxylic acid contains bromine atom in its chemical structure, which may be toxic and irritating. When operating, it is necessary to take appropriate precautions, such as wearing gloves, goggles and protective clothing, and ensure that it is operated in well-ventilated conditions. Also, store the compound properly and avoid contact with oxidants and flammables.

Application
5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid (CAS 916325-85-4) is a multifunctional heterocyclic building block extensively used in medicinal chemistry and drug discovery. Its fused pyrazolo-pyridine core with a carboxylic acid at position 3 and a bromine at position 5 provides distinct synthetic handles for cross-coupling reactions (Suzuki, Buchwald-Hartwig) and amide bond formation. This compound serves as a key intermediate for developing potent kinase inhibitors targeting JAK, BTK, CDK, and other families for treating cancers, inflammation, and autoimmune disorders. The bromine enables late-stage diversification to rapidly explore structure-activity relationships, while the carboxylic acid allows conjugation with amines or alcohols to produce drug-like candidates. It is also utilized in agrochemical research and as a precursor for functionalized heterocycles. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity this compound with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.