5-Bromo-2-methyloxazole-4-carboxylic acid(CAS#1209573-86-3)
Introduction
5-Bromo-2-methyloxazol-4-carboxylic acid is an organic compound. Here is some information about its properties, uses, manufacturing methods and safety:Quality:- Appearance: 5-Bromo-2-methyloxazol-4-carboxylic acid is a white to pale yellow solid.- Solubility: It has low solubility in water and better solubility in organic solvents.- Chemical properties: It is an acidic compound that reacts with alkali to form the corresponding salt.Use:- 5-Bromo-2-methyloxazol-4-carboxylic acid is often used as an intermediate in organic synthesis and can be used in the preparation of other organic compounds.Method:- 5-Bromo-2-methyloxazol-4-carboxylic acid can be prepared by a variety of synthetic routes, one of which is commonly obtained by the reaction of 2-methylthiophene and tetrabromomethane,- The specific synthesis method needs to be operated in the laboratory, and the specific synthesis steps and conditions are not listed here.Safety Information:- 5-Bromo-2-methyloxazol-4-carboxylic acid is generally stable under general operating conditions and has no clear hazards. Like all chemicals, it should be handled with appropriate safety measures and laboratory handling guidelines.When using or handling any chemical, it is important to follow safe operating procedures and relevant regulations.
Application
5-Bromo-2-methyloxazole-4-carboxylic acid (CAS 1209573-86-3) is a functionalized heterocyclic building block widely used in medicinal chemistry and drug discovery. The bromine at the 5-position enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl substituents, while the carboxylic acid at the 4-position allows amide or ester formation. The methyl group at the 2-position provides steric and electronic modulation. This scaffold is a key intermediate for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., PI3K, CDK, and EGFR inhibitors). It also serves as a precursor for antiviral, antibacterial, and antifungal agents. Its rigid oxazole core enhances metabolic stability and target binding affinity. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.


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