5-Oxazolecarboxylic acid, 2-bromo-, methyl ester(CAS#1092351-96-6)
Introduction
Methyl 2-bromooxazole-5-carboxylate is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: Colorless or light yellow liquid- Solubility: Soluble in organic solvents such as ethanol and dimethylformamideUse:Methyl 2-bromooxazole-5-carboxylic acid is an important intermediate in organic synthesis and is often used in the synthesis of biologically active compounds.Method:Methyl 2-bromooxazole-5-carboxylic acid can be prepared by the following steps:2-oxazole carboxylic acid and hydrogen bromide are first reacted to produce 2-bromooxazole-5-carboxylic acid.2-bromooxazole-5-carboxylic acid is then reacted with methanol to give methyl 2-bromooxazole-5-carboxylic acid.Safety Information:When handling methyl 2-bromooxazole-5-carboxylic acid, appropriate safety measures such as wearing protective gloves and eyes should be taken. It can be irritating to the eyes, skin, and respiratory tract and should be avoided. It should be operated in a well-ventilated area to avoid inhaling vapors from this compound.
Application
Methyl 2-bromooxazole-5-carboxylate (CAS 1092351-96-6) is a versatile heterocyclic building block featuring a bromine atom at the 2-position and a methyl ester at the 5-position. The bromine enables efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl substituents, while the methyl ester provides a handle for hydrolysis to carboxylic acid or amidation. This scaffold is widely used in medicinal chemistry for the synthesis of kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., PI3K, CDK, and EGFR inhibitors), as well as antiviral, antibacterial, and antifungal agents. Its rigid, electron-deficient oxazole core enhances metabolic stability and target binding affinity. High purity ensures reproducible results in SAR studies and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
