5-bromoquinolin-8-ol(CAS#1198-14-7)

Application
5-Bromoquinolin-8-ol (5-Bromo-8-hydroxyquinoline, CAS 1198-14-7) is a multifunctional bicyclic heterocycle valued for its dual reactivity as both a metal chelator and a cross-coupling handle. Its 8-hydroxyquinoline core is a privileged pharmacophore in drug discovery, used to develop broad-spectrum antimicrobials, anticancer agents (MMP inhibitors), and neuroprotective candidates targeting metal‑ion dyshomeostasis. The bromine enables Suzuki, Stille, and Buchwald‑Hartwig cross‑couplings to rapidly expand quinoline libraries, while the hydroxyl group forms stable complexes with Cu²⁺, Fe³⁺, and Zn²⁺. Beyond medicinal chemistry, it serves as a water‑soluble, low‑fluorescence caging group with sub‑microsecond two‑photon photolysis, allowing precise release of neurotransmitters and drugs in vivo. This reagent also supports material science applications such as organic semiconductors and fluorescent metal sensors. Xinchem provides custom synthesis and GMP‑grade contract manufacturing of 5-bromoquinolin-8-ol with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.