6-Bromo-2,4-dichloroquinazoline(CAS#102393-82-8)
Introduction
6-Bromo-2, 4-dichloroquinazoline is an organic compound with the formula C9H5BrCl2N2. Its properties include:
1. Appearance: colorless to light yellow crystal or crystalline powder.
2. Solubility: Soluble in organic solvents such as chloroform, ether and alcohol, slightly soluble in water.
3. melting point: about 120-121 degrees Celsius.
6-Bromo-2, 4-dichloroquinazoline has a wide range of uses in the field of medicine and pesticides:
1. Pesticide: It is a pesticide that can be used to control insect pests on a variety of crops, such as apples, wheat, citrus, etc.
2. Antibacterial agent: The compound also has certain antibacterial activity and can be used to treat certain infectious diseases.
The method for preparing 6-bromo-2, 4-dichloroquinazoline generally includes the following steps:
1. reaction precursor: need to use 2-chloro-4-benzamidoquinazoline and cuprous bromide as the precursor of the reaction.
2. reaction conditions: in the corresponding reaction solvent, the reaction precursor is brominated to generate 6-bromo-2, 4-dichloroquinazoline.
3. Crystallization and purification: Through the crystallization process and appropriate purification steps, a higher purity product is obtained.
Regarding safety information, here are some things to note:
1. Wear protective gloves, glasses and masks during operation to avoid direct contact and inhalation.
2. Avoid ingestion, inhalation and skin contact of the compound.
3. When using and storing, keep away from fire and heat sources to avoid fire and explosion.
4. Please keep the compound properly and avoid mixing or mixing with other chemicals to avoid dangerous reactions.
5. If an accident occurs, seek medical attention immediately and bring information about the compound.
Please note that the use and handling of 6-bromo-2, 4-dichloroquinazoline should strictly comply with relevant safety regulations.
Application
6-Bromo-2,4-dichloroquinazoline (CAS 102393-82-8) is a highly functionalized quinazoline derivative bearing three orthogonal leaving groups: a bromine at the 6-position and chlorines at the 2- and 4-positions. This privileged heterocyclic scaffold is a key intermediate in medicinal chemistry for the synthesis of potent tyrosine kinase inhibitors, particularly targeting EGFR, HER2, VEGFR, and BTK in non-small cell lung cancer, breast cancer, and other malignancies. The C4 chlorine undergoes selective nucleophilic aromatic substitution, followed by sequential functionalization at C2 and palladium-catalyzed cross-coupling (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) at C6, enabling rapid construction of diverse polysubstituted quinazoline libraries for structure-activity relationship (SAR) studies. This building block is also utilized in developing antiviral, anti-inflammatory, and antimicrobial agents. Its high purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key API intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
