2,4-Dichloro-5,6,7,8-tetrahydroquinazoline(CAS#1127-85-1)
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
Introduction
2,4-Dichloro-5,6,7,8-tetrahydroquinazoline is an organic compound. It is a white crystalline solid that exists as a crystal at room temperature. The following is an introduction to some of its properties, uses, manufacturing methods and safety information:Quality:- Appearance: White crystalline solid;- Solubility: slightly soluble in water, soluble in most organic solvents;- Stability: Gradually yellows and decomposes when exposed to light.Use:- Chemical synthesis: It can also be used to synthesize other organic compounds such as complexes and condensates, among others.Method:2,4-Dichloro-5,6,7,8-tetrahydroquinazoline can be synthesized by the following steps:- Step 1: Benzoyl chloride and triethyl fluoroborate are reacted under the catalysis of aluminum chloride to form 2-fluorobenzoyl chloride;- Step 2: 2-Fluorobenzoyl chloride is reacted with 2,N-dimethyl-4-aminophenol catalyzed by aluminum chloride to produce 2,4-dichloro-5,6,7,8-tetrahydroquinazoline with a total amount of tetraacetic anhydride.Safety Information:- 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline is a chemical and should be handled with caution;- Avoid inhalation, ingestion, and contact with skin, eyes, and ensure that appropriate personal protective measures are taken during operation;- When used or stored, attention should be paid to its flammability and oxidation;- Use in a well-ventilated environment to avoid inhaling harmful gases or vapors.
Application
2,4-Dichloro-5,6,7,8-tetrahydroquinazoline (CAS 1127-85-1) is a versatile heterocyclic building block widely used in medicinal chemistry and pharmaceutical research. The saturated tetrahydroquinazoline core with two reactive chlorine atoms at the 2- and 4-positions enables sequential nucleophilic aromatic substitution and cross-coupling reactions, allowing selective introduction of diverse amine, aryl, or alkyl groups. This scaffold serves as a key intermediate for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases, including inhibitors of EGFR, BTK, and CDK families. It is also utilized in the development of antiviral, antibacterial, and antifungal agents. The partially saturated ring system provides conformational flexibility and improved metabolic stability compared to fully aromatic quinazolines. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
