6-Iodopyridazin-3-amine(CAS#187973-60-0)

Introduction

6-Iodoidazine-3-amine is an organic compound. It is a yellow solid that is chemically and photostable.It participates in organic synthesis reactions as an intermediate and can synthesize biologically active compounds. It also acts as a protein tyrosine kinase inhibitor with antitumor and antiviral activity.The method for the preparation of 6-iodazine-3-amine can be obtained by the cyclization reaction of isopropanol hydroxylamine. Isopropanol hydroxylamine is reacted with halogenated hydrocarbons to generate N-alkyl isopropylamide; N-alkyl isopropylamide is then reacted with sodium hydroxide and iodine, and a cyclization reaction occurs to form 6-iodopyrazine-3-amine.It may be irritating and allergenic to the human body. During use, it is necessary to take appropriate protective measures, such as wearing gloves, goggles and protective clothing, to avoid inhalation, skin contact and ingestion. It should be stored properly, away from fire and flammable materials. In case of accidental ingestion or contact, seek medical attention immediately. When handling 6-iodazine-3-amine, follow the relevant safety operating procedures.

Application
6-Iodopyridazin-3-amine (3-amino-6-iodopyridazine, CAS 187973-60-0) is a versatile heterocyclic building block featuring a reactive iodine atom at the 6-position and an amino group at the 3-position. The iodine enables efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Stille, Sonogashira, Buchwald-Hartwig) for rapid introduction of aryl, heteroaryl, or alkyl substituents, while the amino group allows acylation, alkylation, or amide formation. This scaffold is widely used in medicinal chemistry and drug discovery for the synthesis of kinase inhibitors (e.g., PI3K, mTOR, CDK), antiviral agents, and anti-inflammatory compounds. Its pyridazine core is also found in agrochemicals (herbicides, fungicides) and materials such as fluorescent probes. High purity ensures reproducible SAR studies and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.