7-Bromoisoquinolin-3-amine(CAS#1192815-02-3)

Introduction

7-Bromoisoquinoline-3-amine is an organic compound.Quality:7-Bromoisoquinoline-3-amine is a solid and can be white or light yellow crystals. It is stable at room temperature, but prolonged exposure to air should be avoided. It is soluble in solution in some organic solvents such as methylene chloride, carbon disulfide, and alcohols.Use:7-Bromoisoquinoline-3-amine is widely used as a reagent and intermediate in organic synthesis.Method:There are several methods for the synthesis of 7-bromoisoquinoline-3-amine. A common method is to react isoquinoline with a brominating agent so that it undergoes a substitution reaction at position 7 to form 7-bromoisoquinoline. Subsequently, by reacting with an amination agent, an amine group is introduced into the molecule to synthesize 7-bromoisoquinoline-3-amine.Safety Information:When using 7-bromoisoquinoline-3-amine, general laboratory safety practices should be followed. It can have an irritating effect on the eyes, skin, and respiratory tract. Direct contact should be avoided and, if necessary, appropriate protective equipment such as gloves and glasses should be worn. When storing and handling, it should be kept in an airtight container, away from ignition and oxidants. Follow the relevant regulations and guidelines for safe operation.

Application
7-Bromoisoquinolin-3-amine (CAS 1192815-02-3) is a versatile heterocyclic building block featuring a bromine atom at the 7-position and an amino group at the 3-position on the isoquinoline core. It enables cross-coupling (Suzuki-Miyaura, Buchwald-Hartwig) and nucleophilic substitution at the bromide handle, while the primary amine facilitates acylation, sulfonylation, or reductive amination for rapid structure-activity relationship studies. This pharmacophore is utilized in the synthesis of SIK2 and IRE1 inhibitors, as well as kinase inhibitors targeting various therapeutic areas. Its isoquinoline core is associated with antitumor, antimicrobial, anti-inflammatory, and CNS activities, making it a valuable intermediate for drug discovery. High-purity material ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 7-Bromoisoquinolin-3-amine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.