CARYOPHYLLENE OXIDE(CAS#1139-30-6)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/38 - Irritating to eyes and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 2 |
| RTECS | RP5530000 |
| FLUKA BRAND F CODES | 1-10 |
| HS Code | 29109000 |
CARYOPHYLLENE OXIDE， CAS number is 1139-30-6.
It is a naturally occurring sesquiterpene compound commonly found in various plant essential oils, such as cloves, black pepper, and other essential oils. In appearance, it is usually a colorless to pale yellow liquid.
In terms of smell characteristics, it has a unique smell of wood and spice, which makes it popular in the spice industry. It is often used to mix perfume, air freshener and other products, adding a unique and charming fragrance level to it.
In the field of medicine, it also has certain research value. Some preliminary studies suggest that it may have potential activities such as anti-inflammatory and antibacterial, but more in-depth experiments are needed to fully explore its medicinal efficacy.
In agriculture, it can also serve as a natural insect repellent, helping to drive away some pests on crops and reduce the use of chemical pesticides, which is in line with the current trend of green agriculture development.
Application
Caryophyllene oxide (CAS 1139-30-6, FEMA 4085, JECFA 1575) is a natural bicyclic sesquiterpenoid produced by the oxidation of β‑caryophyllene. It is recognized as safe (GRAS 21CFR172.515) and widely approved as a flavoring agent in food, beverages, baked goods, confectionery, oral care, and pet food, where it contributes woody, spicy, peppery, dry tea, black pepper, hops, clove, tobacco, herbaceous, camphoraceous, amber, and balsamic notes at typical use levels of 0.5‑20 mg/kg. As a fragrance ingredient, it acts as an effective substantive fixative and natural base‑note modifier in fine perfumery, colognes, aftershaves, soaps, shampoos, shower gels, laundry detergents, fabric softeners, candles, diffusers, and household cleaners, providing excellent longevity and depth to woody, fougère, oriental, amber, and spicy accords. In cosmetics and personal care, it is used for its skin‑conditioning, repair‑promoting, protective, and UV‑stabilizing properties in creams, lotions, serums, and sunscreens. Pharmaceutical research has identified caryophyllene oxide as a potent analgesic, anti‑inflammatory (downregulating TNF‑α, IL‑1β, NF‑κB, and COX‑2), antimicrobial (effective against Gram‑positive/‑negative bacteria and fungi), antioxidant, antiviral, anticancer (cytotoxic to HepG2, HeLa, MCF‑7, and other cell lines), antifungal (e.g., against Candida and dermatophytes), and acaricidal agent. It is also studied as a calcium channel blocker, muscle relaxant, and repellent (superior to DEET in some models). In agriculture, it serves as a natural biopesticide and fungicide, while in veterinary and material science it is used in repellent formulations, bio‑based polymers, and industrial additives. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high‑purity (≥98%) caryophyllene oxide with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
