Ethyl (R)-(+)-4-chloro-3-hydroxybutyrate（CAS# 90866-33-4)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/39 - |
| UN IDs | 2810 |
| WGK Germany | 3 |
| HS Code | 29181990 |
| Hazard Class | 6.1 |
| Packing Group | III |
Introduction
Ethyl (R)-(+)-4-chloro-3-hydroxybutyrate is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:
Quality:
- Ethyl (R)-(+)-4-chloro-3-hydroxybutyrate is a solid with a special chemical structure.
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- This is a chiral compound with stereoisomers present. Ethyl (R)-(+)-4-chloro-3-hydroxybutyrate is an isomer of dextrophone.
- It is soluble in ethanol and ether and slightly soluble in water.
Use:
- Ethyl (R)-(+)-4-chloro-3-hydroxybutyrate is an important intermediate compound used in organic synthesis reactions.
- This compound is also used as a catalyst and ligand.
Method:
- The preparation method of ethyl (R)-(+)-4-chloro-3-hydroxybutyrate involves a multi-step synthesis process.
- Specific preparation methods and reaction conditions may vary depending on the investigator and the literature.
Safety Information:
- Ethyl (R)-(+)-4-chloro-3-hydroxybutyrate generally has low toxicity under proper use and storage conditions.
- But it is still a chemical and needs to follow proper laboratory safety operating procedures.
- During handling and handling, avoid direct contact with skin and eyes, use chemical protective gloves and goggles.
- When storing, it should be stored in a dry, cool, well-ventilated place, away from fire and flammable materials.
Application
Ethyl (R)-(+)-4-chloro-3-hydroxybutyrate ((R)-CHBE, CAS 90866-33-4) is a high-purity chiral building block widely used as a key pharmaceutical intermediate and versatile synthon in asymmetric synthesis. Its defined (R)-configuration and dual functional groups (chloride and ester) enable selective transformations for constructing complex chiral molecules. In pharmaceutical manufacturing, (R)-CHBE serves as a critical precursor for the cholesterol-lowering drug atorvastatin (Lipitor®), as well as for L-carnitine, (R)-4-amino-3-hydroxybutyric acid, (R)-4-hydroxy-pyrrolidone, and other bioactive compounds. Recent reports also highlight its use in novel synthetic routes for super statins. In medicinal chemistry, this chiral intermediate supports the synthesis of HMG-CoA reductase inhibitors, antibiotics, and natural products such as Slagenins B and C. Its high enantiomeric purity (≥96% ee) ensures reproducible results in drug discovery, SAR studies, and GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity Ethyl (R)-(+)-4-chloro-3-hydroxybutyrate with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
