Isoamyl nitrite(CAS#110-46-3)
| Risk Codes | R11 - Highly Flammable R20/22 - Harmful by inhalation and if swallowed. |
| Safety Description | S16 - Keep away from sources of ignition. S24 - Avoid contact with skin. S46 - If swallowed, seek medical advice immediately and show this container or label. |
| UN IDs | UN 1113 3/PG 2 |
| WGK Germany | 1 |
| RTECS | NT0187500 |
| FLUKA BRAND F CODES | 1-8-9 |
| TSCA | Yes |
| HS Code | 29209090 |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: 505 mg/kg |
Introduction
Isoamyl nitrite. The following is an introduction to the properties, uses, preparation methods and safety information of isoamyl nitrite:- Isoamyl nitrite is a colorless or yellowish liquid with a peculiar pungent odor. - Isoamyl nitrite is soluble in water and organic solvents and reacts with other compounds. Uses:- The main use of isoamyl nitrite is as an important intermediate in organic synthesis. - It is commonly used in the preparation of other organic compounds such as ketones and alcohols. - It can also be used to synthesize plant-based essential oils and synthetic fragrance substances. Preparation method:- Isoamyl nitrite can be prepared by the reaction of isoamyl alcohol with sodium nitrite. - Under reaction conditions, isoamyl nitrite is generated by controlling the reaction temperature and pH. Safety Information:- Isoamyl nitrite is highly irritating and toxic, and is a flammable liquid. - During use, avoid contact with skin, eyes, and respiratory tract, and prevent swallowing. - Wear appropriate protective equipment such as chemical gloves, protective glasses, and protective clothing when operating. - During storage and handling, keep away from fire and heat sources and maintain a well-ventilated environment. - Waste disposal should be carried out in accordance with local laws and regulations to avoid environmental pollution.
Application
Isoamyl nitrite (CAS 110-46-3), also known as isopentyl nitrite or amyl nitrite, is a nitrite ester widely used as a pharmaceutical intermediate, organic synthesis reagent, and fine chemical. In pharmaceutical applications, it acts as a fast-acting vasodilator for the treatment of angina pectoris and hypertension, and serves as a cyanide poisoning antidote by converting hemoglobin to methemoglobin, which binds cyanide to form non‑toxic cyanmethemoglobin. In organic synthesis, isoamyl nitrite is utilized as a nitrosating agent, oxidant, and radical initiator. It is employed for the generation of benzyne from anthranilic acid, functionalization of multi‑walled carbon nanotubes, and synthesis of diazonium salts. The compound is also used in the preparation of 4-carboxy‑phenyl diazonium salt tetrafluoroborate and as a nitrosating agent for phosphoramidites. In the flavor and fragrance industry, it is an intermediate for perfume preparation and an ingredient in room odorizers. Additional applications include its use as a solvent and chelating agent in industrial formulations. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high‑purity isoamyl nitrite with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
