N-N-Bis 9-fluorenylmethyloxycarbonyl-L-histidine CAS 98929-98-7

Introduction

Toxin peptides are a class of toxic peptide molecules, usually produced by bacteria, plants, or animals. The properties of toxin peptides depend on their structure and source, and some are neurotoxic, cytotoxic, or otherwise biological. CALCISEPTINE IS A TOXIN PEPTIDE WITH CAS NUMBER 178805-91-9, AND ITS SPECIFIC PROPERTIES REQUIRE FURTHER INVESTIGATION.

The preparation of toxin peptides usually needs to be extracted from living organisms or obtained by synthetic methods, and the preparation process can be complex and requires professional technical support.

Toxin peptides are potentially toxic, and the dosage and concentration need to be strictly controlled when used to avoid harm to the human body or the environment. When operating in the laboratory, you need to wear personal protective equipment and follow the relevant safety operating procedures. For the research and application of toxin peptides, relevant regulations and safety standards should be followed to ensure the safety of people and the environment.

Application
Nα,Im-Bis-Fmoc-L-histidine (Bis-Fmoc-histidine, CAS 98929-98-7) is a specialized derivative for Fmoc solid-phase peptide synthesis (SPPS). It features the base-labile Fmoc group protecting both the α-amino group and the reactive imidazole side chain. This dual protection effectively prevents unwanted side reactions, such as acylation or alkylation of the imidazole nitrogen, ensuring high-fidelity chain assembly for histidine-containing sequences. It is a critical building block for generating complex therapeutic peptides, including peptide hormones, antimicrobial peptides, and enzyme inhibitors. In pharmaceutical research, this derivative enables the reliable synthesis of histidine-rich bioactive motifs found in metalloproteins, antibody-drug conjugates (ADCs), and peptide-based drug candidates targeting cancer and metabolic disorders. After chain assembly, both Fmoc groups are removed under standard piperidine conditions, streamlining the synthesis workflow. Available in high purity (≥98%) and as a crystalline solid, it is fully compatible with automated SPPS instrumentation. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of Fmoc-His(Fmoc)-OH for research, process development, and GMP-scale peptide production. Contact us for a competitive quote and reliable global supply.