2,3,4-Trifluoroaniline(CAS#3862-73-5)
| Risk Codes | R21/22 - Harmful in contact with skin and if swallowed. R38 - Irritating to the skin R41 - Risk of serious damage to eyes R48/22 - Harmful danger of serious damage to health by prolonged exposure if swallowed. R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3082 9/PG 3 |
| WGK Germany | 3 |
| RTECS | CY1211500 |
| FLUKA BRAND F CODES | 9 |
| HS Code | 29214210 |
| Hazard Note | Irritant |
| Hazard Class | 9 |
| Packing Group | III |
| Toxicity | LD50 orl-rat: 699 mg/kg JACTDZ 1,61,90 |
Introduction
2,3,4-Trifluoroaniline is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- 2,3,4-Trifluoroaniline is a colorless liquid with a pungent odor.- At room temperature, it is soluble in organic solvents such as ether and alcohols, and almost insoluble in water.Use:- 2,3,4-Trifluoroaniline has important applications in the field of organic synthesis.- It can be used as a synthetic intermediate for dyes and pigments.- 2,3,4-Trifluoroaniline can also be used as a resist on metal surfaces and as a material for some electronic devices.Method:- The preparation of 2,3,4-trifluoroaniline can be obtained by reacting aniline with trifluoromethanesulfonic acid.- Under the right conditions, aniline is reacted with trifluoromethanesulfonic acid to form aniline sulfonate.- Then, aniline sulfonate is reacted with hydrofluoric acid to give 2,3,4-trifluoroaniline.Safety Information:- 2,3,4-Trifluoroaniline is irritating and may cause damage to the eyes, skin, and respiratory system.- When in use, wear appropriate protective equipment such as chemical protective glasses, gloves, and respiratory protection.- Avoid prolonged contact with the skin and inhalation of its vapors.- When handling and storing, care should be taken to prevent contact with oxidants and strong oxidants, and avoid ignition sources and high temperatures.
Application
2,3,4-Trifluoroaniline is a high‑purity fluorinated building block used as a key pharmaceutical intermediate in the synthesis of fluoroquinolone antibiotics, including lomefloxacin and norfloxacin. It also serves as a core scaffold for the preparation of antibacterial drugs such as ofloxacin and enoxacin. In crop protection, this versatile halogenated aniline is utilized to produce herbicides, fungicides, and pesticides, where the fluorine atoms improve metabolic stability and target selectivity. It also functions as a precursor for fluorinated polymers and specialty chemicals used in advanced coatings and materials. Xinchem offers high-purity 2,3,4-Trifluoroaniline with reliable custom synthesis, custom chemical synthesis, and contract manufacturing, scaled from R&D to commercial tons. Contact us for a competitive quote and global supply.
