3-Chloro-4-fluoroaniline(CAS#367-21-5)
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R33 - Danger of cumulative effects R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 2 |
| FLUKA BRAND F CODES | 9-23 |
| TSCA | T |
| HS Code | 29214210 |
| Hazard Note | Irritant/Toxic |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 506 mg/kg |
Introduction
3-Chloro-4-fluoroaniline is an organic compound. It is a colorless to yellowish crystal with a special smell.3-Chloro-4-fluoroaniline has a wide range of uses. In the chemical industry, it can be used as an intermediate for dyes and pigments in the production of dyes, pigments and coatings.There are several ways to prepare 3-chloro-4-fluoroaniline. A common method is to react 4-fluorobenzene chloride with ammonia to obtain 3-chloro-4-fluoroaniline. The specific reaction conditions and steps can be adjusted according to the actual needs.Safety information, 3-chloro-4-fluoroaniline is generally relatively safe under normal use conditions. As a chemical, it can still pose some level of risk to health and the environment. Appropriate safety measures such as wearing protective gloves, glasses, and masks should be taken when handling and storing. Avoid contact with oxidizing agents and strong acids to avoid initiating dangerous chemical reactions. In case of accidental conditions such as inhalation, skin contact or accidental ingestion, seek medical attention immediately. When using or handling 3-chloro-4-fluoroaniline, be sure to refer to the relevant safety operating procedures and follow the safety measures of the laboratory.
Application
3-Chloro-4-fluoroaniline (CAS 367-21-5) is a multifunctional halogenated aniline used as a key building block in pharmaceutical and agrochemical research. In drug discovery, it serves as a critical intermediate for the synthesis of fluoroquinolone antibiotics, including ciprofloxacin and norfloxacin analogs, as well as anticancer agents and kinase inhibitors. The strategic combination of electron-withdrawing chlorine and fluorine substituents enhances metabolic stability and target binding affinity. In agrochemistry, this compound is utilized to prepare selective herbicides, fungicides, and insecticides with improved crop protection efficacy and environmental safety. The aromatic amine functionality allows diazotization, nucleophilic substitution, and palladium-catalyzed cross-coupling reactions for rapid structure-activity relationship (SAR) studies. Additionally, it is employed in the production of dyes, pigments, and functional polymers. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers reliable custom synthesis and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
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