3,3-difluorocyclopentanaMine HCl(CAS#939398-48-8)
Introduction
3, HCl is an organic compound, the chemical formula is C5H9F2N · HCl. It is a colorless crystalline solid, stable at room temperature. The following is a description of the properties, uses, methods and safety information of 3,-HCl:
Nature:
-Appearance: Colorless crystalline solid
-Molecular weight: 153.59g/mol
-melting point: about 130-134 ℃
-Boiling Point: No public data
-Solubility: Soluble in water
Use:
-Pharmaceutical research: 3. HCl is often used as an organic synthetic intermediate in the field of pharmaceutical research to synthesize drugs or drug candidate compounds.
-Organic synthesis: It can be used as an important reagent in organic synthesis and used to prepare other organic compounds.
Method:
3. The preparation method of HCl can use a variety of routes. The following is a common synthesis method:
1.3,3-difluorocyclopentanone and ammonia are reacted in ethanol to generate 3,3-difluorocyclopentylamine.
2. Dissolve, 3-difluorocyclopentylamine in dilute hydrochloric acid, crystallize and dry to obtain 3,3-HCl.
Safety Information:
- 3, HCl should be regarded as an organic compound, and personal protective measures should be taken when using it, such as wearing protective glasses and gloves.
-in the operation, to avoid the inhalation of dust or vapor, need to operate in a well ventilated place.
-Keep away from ignition and igniting objects to avoid fire.
- 3, HCl should be stored in a dry, cool and sealed container, away from oxidizing agents and acids.
Please note that the above information is for reference only. Please refer to the relevant laboratory operation manual and safety guide for specific operation.
Application
3,3-Difluorocyclopentanamine hydrochloride (CAS 939398-48-8) is a key fluorinated pharmaceutical intermediate used extensively in medicinal chemistry and drug discovery. As a gem-difluorinated cyclopentylamine scaffold, it serves as a powerful building block for generating small-molecule libraries and drug-like compounds, where the gem-difluoro substitution pattern modulates molecular properties including metabolic stability, lipophilicity, and conformational bias while introducing minimal steric bulk. This advanced organic intermediate is particularly valuable for the synthesis of CNS drug candidates targeting neurological and psychiatric disorders such as Alzheimer's disease, schizophrenia, and depression, having also been studied as an α7 nicotinic acetylcholine receptor agonist for treating cognitive impairment. Beyond therapeutic agents, 3,3-difluorocyclopentanamine hydrochloride is a versatile synthetic intermediate for producing agrochemicals, specialty chemicals, enzyme inhibitors, receptor ligands, and functional materials, making it an essential tool in pharmaceutical R&D, custom chemical synthesis, and process chemistry applications. Xinchem offers high-purity 3,3-difluorocyclopentanamine hydrochloride with reliable custom synthesis, custom chemical synthesis, and flexible contract manufacturing, scaled from R&D to commercial tons. Contact us for a competitive quote and dependable global supply.
