4-chloro-2,6-dimethyl-pyrimidine(CAS#4472-45-1)

Introduction

4-choro-2, 6-dimethy1-pyrimidine is an organic compound with the chemical formula C6H7ClN2. The following is a description of its nature, use, preparation and safety information:

Nature:

4-chloro-2,6-dimethyl-pyrimidine is a colorless to pale yellow crystal or powder with a special odor. It exists in a solid state at room temperature and can be dissolved in organic solvents such as ethanol and dichloromethane. This compound has a relatively low melting and boiling point.

Use:

4-choro-2, 6-dimethyl-pyrimidine is widely used as an intermediate in organic synthesis. It can be used in the synthesis of pesticides, pharmaceuticals and other organic compounds. In addition, it can also be used as a raw material for analytical reagents and pesticides.

Preparation Method:

The preparation of 4-choro-2, 6-dimethy1-pyrimidine is usually achieved by chemical synthesis methods. A common preparation method is to react 2,4-dimethyl pyrimidine with chloroacetic acid or chloroacetic anhydride, and carry out nucleophilic substitution reaction under appropriate reaction conditions to obtain the product.

Safety Information:

4-chloro-2,6-dimethyl-pyrimidine is irritating and should avoid contact with skin, eyes and respiratory tract. During use and storage, care should be taken to avoid light, keep dry and keep away from fire sources. Appropriate protective equipment, such as lab gloves, goggles and protective masks, should be worn during operation. After contact with the compound, the affected area should be flushed immediately with plenty of water and medical help should be sought immediately.

Application

4-Chloro-2,6-dimethylpyrimidine (CAS 4472-45-1) is a high-purity, strategically substituted pyrimidine heterocycle featuring a single chlorine at C4 and methyl groups at C2 and C6. This specific substitution pattern makes it an indispensable building block in medicinal chemistry and drug discovery, as the chlorine is highly reactive toward nucleophilic aromatic substitution (SNAr) and palladium-catalyzed cross-coupling reactions. As a key pharmaceutical intermediate, it is utilized to synthesize selective kinase inhibitors targeting cancer, inflammatory diseases, and autoimmune disorders, as well as antiviral and antibacterial drug candidates. The two methyl groups ensure excellent metabolic stability and binding selectivity. In agrochemistry, it serves as a core scaffold for developing next-generation herbicides, fungicides, and insecticides with favorable crop safety. It also supports the synthesis of functional materials and specialty polymers. The compound’s high reactivity permits regioselective modifications without requiring protecting groups, enabling rapid structure-activity relationship studies. Xinchem is a premier manufacturer and supplier of 4-chloro-2,6-dimethylpyrimidine. Our advanced custom synthesis and contract manufacturing capabilities ensure consistent high purity and reliable global supply, with flexible scaling from R&D samples to commercial tons. Contact us today for a competitive quote.