5-Azaindole(CAS#271-34-1)
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S39 - Wear eye / face protection. |
| RTECS | UY8725000 |
| HS Code | 29339980 |
| Hazard Note | Irritant |
Introduction
5-Nitroindazole is an organic compound containing nitrogen and oxygen atoms. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- 5-Azaindole is a yellow solid with low solubility.- It is stable in solvents but sensitive to oxygen and light.- It has strong oxidation and toxicity.Use:- It can also be used as a chemical reagent in the laboratory for the synthesis of other compounds.Method:- 5-Azaindole can be obtained by reacting 5-nitroindole with nucleophiles such as amine compounds.- The specific preparation method can be adjusted according to different literature and needs.Safety Information:- 5-Azaindole is a potentially harmful substance and should be disposed of properly.- Appropriate precautions such as safety glasses, gloves and protective clothing are required during operation.- It should be forbidden to come into contact with substances such as strong oxidants, flammable substances, etc., to avoid dangerous accidents.- When using or disposing of, the relevant regulations and guidelines regarding chemical safety and waste disposal need to be followed.
Application
5-Azaindole (CAS 271-34-1), also known as 1H-pyrrolo[3,2-b]pyridine, is a versatile heterocyclic scaffold widely used in medicinal chemistry and drug discovery. As a purine bioisostere, it serves as a key building block for the synthesis of kinase inhibitors targeting cancer, inflammation, and autoimmune disorders (e.g., JAK, BTK, CDK, and PI3K inhibitors). The fused pyrrole-pyridine core enables functionalization at multiple positions, allowing rapid structure-activity relationship (SAR) exploration. 5-Azaindole is also employed in the development of antiviral agents, CNS drugs, and agrochemicals. Its rigid, planar structure enhances target binding affinity and metabolic stability. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 5-azaindole with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
