(5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-ACETONITRILE（CAS# 95727-86-9)

Introduction

5-(trifluoromethyl)pyridine-2-carbonitrile(5-(trifluoromethyl)pyridine-2-carbonitrile) is an organic compound with the chemical formula C7H2F3N.

Nature:

5-(trifluoromethyl)pyridine-2-carbonitrile is a colorless liquid with a unique smell. It has a density of about 1.34 g/mL and a boiling point of 162-165°C.

Use:

5-(trifluoromethyl)pyridine-2-carbonitrile is an important organic synthesis intermediate, which is widely used in medicine, pesticide, material science and other fields. It can be used to synthesize anticancer drugs, insecticides and some organic photoelectric materials.

Preparation Method:

5-(trifluoromethyl)pyridine-2-carbonitrile is prepared by various methods, mainly including the following:

1. by 2-cyano-5-bromomethylpyridine and trifluoromethyl bromide reaction.

2. 2-Cyano-5-methylpyridine is reacted with trifluoromethyl bromide in the presence of sodium chloride at high temperature.

Safety Information:

Because 5-(trifluoromethyl)pyridine-2-carbonitrile has an irritating effect on the eyes, skin and respiratory tract, care should be taken to avoid contact when using it. If you come into contact with the substance, rinse immediately with plenty of water and seek medical help. In addition, it is also a flammable liquid and should be stored away from fire sources and high temperature environments, and pay attention to fire and explosion prevention. During use and storage, please follow the relevant safety practices.

Application

(5-Trifluoromethyl-pyridin-2-yl)-acetonitrile (2-Cyano-5-(trifluoromethyl)pyridine, CAS 95727-86-9) is a high-value fluorinated pyridine building block. It is an important organic synthesis intermediate widely used in pharmaceuticals, agrochemicals, and material science. The strategic combination of a strong electron-withdrawing trifluoromethyl group and a reactive nitrile (acetonitrile) functionality enables diverse transformations, including hydrolysis to acids, reduction to amines, and participation in heterocycle condensations, making it a versatile precursor for constructing complex drug-like scaffolds. It is a key intermediate in the synthesis of anticancer drugs, insecticides, and organic photoelectric materials, with ongoing research exploring its antimicrobial, antifungal, and other biological activities. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity (5-Trifluoromethyl-pyridin-2-yl)-acetonitrile with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.