6-BroMo-3,4-dihydroquinazolin-2(1H)-one(CAS#1246765-38-7)
Introduction
6-Bromo-3,4-dihydroquinazoline-2-one is an organic compound. The following is an introduction to some of the properties, uses, preparation methods, and safety information of this compound:Quality:Appearance: 6-Bromo-3,4-dihydroquinazolin-2-one is a white solid.Solubility: This compound has some solubility in some organic solvents, such as dimethyl sulfoxide and dimethylformamide.Use:Chemical research: its structural characteristics and reactivity, it can also be used in some synthetic reactions in organic chemistry research.Method:6-Bromo-3,4-dihydroquinazolin-2-one can be synthesized by a variety of methods, one of the most common methods is the bromination of 3,4-dihydroquinazolin-2(1H)-one using bromide.Safety Information:6-Bromo-3,4-dihydroquinazoliline-2-one should follow the safe operating procedures of general chemicals when stored and handled.The compound belongs to bromide and should be noted for its possible irritation and harm to the skin, eyes, and respiratory system.In case of accidental contact with this compound, rinse immediately with plenty of water and seek medical attention.
Application
6-Bromo-3,4-dihydroquinazolin-2(1H)-one (CAS 1246765-38-7) is a saturated quinazolinone derivative featuring a bromine atom at the 6-position. This heterocyclic building block is valued in medicinal chemistry for the synthesis of bioactive molecules, including kinase inhibitors, antiviral agents, and anticancer compounds. The reduced 3,4-dihydro core offers conformational flexibility compared to aromatic quinazolinones, while the 2-one lactam provides hydrogen bond donor/acceptor sites. The bromine enables cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) for introducing diverse aryl, heteroaryl, or alkyl substituents, facilitating structure-activity relationship (SAR) studies. This scaffold is also utilized in developing anti-inflammatory, antimicrobial, and CNS-targeting drugs. Its high purity ensures reproducible results in drug discovery and scalable synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
