Cetrorelix(CAS#120287-85-6)

Introduction

Cetrorelix is an organic synthetic compound with the chemical name of 1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazine-3-yl)pentyl-3-ol. It is a white to light yellow crystalline powder.Cetrorelix is mainly used in agriculture as an insecticide and herbicide. It has a good killing effect on a variety of insects, mites and weeds, and can be applied to the protection of fruit trees, vegetables, cotton and other crops. It can also be used to prevent viruses spread by aphids.The preparation method of cetrorelix is generally obtained by chemical synthesis. Its synthesis methods include the alcohol amine method and the Grignard reagent method. The alcohol amine method mainly reacts alcohol amine with parachlorobenzoate with triazine substrate to generate precursors, and then further hydrolyzes the acid to synthesize cetrorelix. The Grignard reagent method is to obtain cetrorelix by reacting Grignard reagent with parachlorobenzoate and triazine base.Cetrorelix is a toxic substance that may cause irritation and allergic reactions if it comes into contact with the skin or inhales its dust. Wear appropriate protective equipment such as gloves, protective glasses and masks when in use. Follow the relevant safety practices and avoid direct contact with or ingestion of cetrorelix. When disposing of waste, proper treatment and disposal should be carried out in accordance with local regulations.

Application
Cetrorelix (Cetrorelix Acetate, CAS 120287-85-6) is a synthetic decapeptide that functions as a potent and competitive gonadotropin-releasing hormone (GnRH) antagonist. It acts by reversibly blocking GnRH receptors in the anterior pituitary gland, leading to a rapid, dose-dependent suppression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion. This pharmacological action prevents premature ovulation, allowing oocytes to mature fully before retrieval. Clinically, Cetrorelix is extensively used as an active pharmaceutical ingredient (API) in assisted reproductive technologies (ART), specifically in controlled ovarian stimulation protocols for in vitro fertilization (IVF), where it helps improve pregnancy outcomes in women undergoing fertility treatment. It is also being investigated for its therapeutic potential in hormone-sensitive cancers, such as prostate, breast, and ovarian cancers, and in treating endometriosis. Common formulations include Cetrorelix Acetate for Injection, which is supplied as a lyophilized powder for subcutaneous administration. High-purity Cetrorelix is essential for pharmaceutical formulation, analytical method development (AMD), and quality control (QC) and is utilized as a reference standard for impurity profiling and stability studies. As a versatile peptide building block and pharmaceutical intermediate, it is also employed in peptide synthesis research, degradation pathway studies, and the development of novel GnRH antagonists. Xinchem provides reliable custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity Cetrorelix, with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and global supply.