N-Boc-propargylamine（CAS# 92136-39-5)

Introduction

N-Boc-aminopropylene is an organic compound. The following is an introduction to some of the properties, uses, preparation methods and safety information of N-Boc-aminopropyne:

Quality:

- Appearance: White crystalline solid

- Solubility: soluble in organic solvents such as dichloromethane, dimethylformamide, etc., insoluble in water

- Stability: Relatively stable under light and can be stored for a long time

Use:

- N-Boc-aminopropyne is an important intermediate in organic synthesis, which is often used in the synthesis of compounds containing alkyne groups, such as those containing amide and imide groups.

Method:

A common preparation method of N-Boc-aminopropylene is to react propynylcarboxylic acid with N-tert-butoxycarbonylcarboxamide to produce N-Boc-aminopropylene. This reaction needs to be carried out by a chemical reaction device at the appropriate temperature and reaction time.

Safety Information:

N-Boc-aminopropynyl is an organic compound, and the following safety precautions should be taken during operation:

- Avoid inhaling, ingestion, or contact with skin, eyes, etc. during operation. Wear appropriate protective equipment such as gloves, goggles, and a lab coat when necessary.

- When storing, N-Boc-aminopropynyl should be kept tightly sealed and stored in a dry, cool place, away from fire sources and oxidants, etc.

- In the event of an accident, stop work immediately and take appropriate emergency measures.

When using N-Boc-aminopropyne or performing related experiments, it is important to follow laboratory safety practices and professional guidance.

Application
N-Boc-propargylamine is a key intermediate in the synthesis of triazolobenzylidene-thiazolopyrimidines, which act as CDC25 phosphatase inhibitors—enzymes that are critical regulators of cell cycle progression and potential targets for cancer therapy. Furthermore, it is utilized in the synthesis of beta-glucan polysaccharide analogs. As a click chemistry reagent, it contains an alkyne group that readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with azide-containing molecules, enabling the efficient construction of complex molecular architectures. In pharmaceutical development, it serves as an important intermediate for the synthesis of various drugs, particularly those targeting neurological disorders such as Parkinson’s and Alzheimer’s disease, with derivatives like rasagiline and selegiline being notable examples. Its protected amine functionality allows for selective deprotection and further functionalization, making it a versatile and stable intermediate for organic synthesis, medicinal chemistry, and bioconjugation applications. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity N-Boc-propargylamine with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.