N(alpha)-boc-N(omega)-tosyl-L-arginine （CAS#13836-37-8）
Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 2935 90 90 |
| Hazard Class | IRRITANT |
Introduction
Toxin peptides are a class of toxic peptide molecules, usually produced by bacteria, plants, or animals. The properties of toxin peptides depend on their structure and source, and some are neurotoxic, cytotoxic, or otherwise biological. CALCISEPTINE IS A TOXIN PEPTIDE WITH CAS NUMBER 178805-91-9, AND ITS SPECIFIC PROPERTIES REQUIRE FURTHER INVESTIGATION.
The preparation of toxin peptides usually needs to be extracted from living organisms or obtained by synthetic methods, and the preparation process can be complex and requires professional technical support.
Toxin peptides are potentially toxic, and the dosage and concentration need to be strictly controlled when used to avoid harm to the human body or the environment. When operating in the laboratory, you need to wear personal protective equipment and follow the relevant safety operating procedures. For the research and application of toxin peptides, relevant regulations and safety standards should be followed to ensure the safety of people and the environment.
Application
Boc-Arg(Tos)-OH (Nα-Boc-Nω-tosyl-L-arginine) is a standard building block for introducing arginine residues by Boc solid-phase peptide synthesis (Boc SPPS). The Boc group provides acid-labile protection for the α-amine, while the tosyl (Tos) group permanently masks the nucleophilic guanidino side chain, preventing branching and other side reactions during chain assembly. This orthogonally protected derivative is essential for constructing complex peptides containing arginine, including bioactive sequences such as RGD tripeptides, HIV-1 protease substrates, and various therapeutic candidates. Its high purity and stability ensure efficient coupling with standard reagents (e.g., DCC, HOBt, EDCI), allowing reliable elongation of peptide chains. After completion of synthesis, the Boc group is removed with TFA, and the Tos group is cleaved by strong acids like hydrogen fluoride (HF) or TFMSA. Boc-Arg(Tos)-OH is indispensable in medicinal chemistry and biochemical research, where precise control over arginine incorporation is required to study protein-protein interactions, enzyme mechanisms, and to develop peptide-based drugs. Xinchem offers custom synthesis and contract manufacturing of this high-purity derivative with flexible scaling from R&D to commercial volumes. Contact us for a competitive quote and reliable global supply.
