Ethyl(R)-(-)-2-hydroxy-4-phenylbutyrate(CAS#90315-82-5)
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29181990 |
Introduction
Ethyl (R)-2-hydroxy-4-phenylbutyric acid, also known as (R)-2-Hydroxy-4-phenylbutyric acid ethyl ester, is an organic compound. Here are some properties and information about this compound:Properties:- Appearance: Colorless or light yellow liquid- Solubility: Good solubility in common organic solventsUses:- (R)-2-hydroxy-4-phenylbutyrate ethyl ester is a chiral carbon containing a compound with important optical activity. Preparation method: - (R)-2-hydroxy-4-phenylbutyrate ethyl ester can be prepared by a variety of synthesis methods, one of the commonly used methods is through the conversion of (2R)-malic acid. Malic acid is first subjected to anhydride to obtain malic anhydride, and then reacts with phenylmethanol to obtain ethyl (R)-2-hydroxy-4-phenylbutyrate. Safety Information:- (R)-2-hydroxy-4-phenylbutyrate ethyl butyrate is less toxic, but should still be used and stored properly. - It may cause irritation to the eyes, skin, and respiratory tract, and care should be taken to avoid direct contact when operating. - When handling the compound, appropriate personal protective measures such as gloves, protective eyewear, and protective masks should be taken. - When storing, it needs to be kept in a dry, cool place, away from fire and oxidants. - If the substance is ingested or inhaled, seek medical attention promptly.
Application
Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate (R-HPBE) is a high-purity chiral building block that serves as a key intermediate in the synthesis of Angiotensin-Converting Enzyme (ACE) inhibitors. It is extensively utilized in the industrial production of leading antihypertensive APIs such as Cilazapril, Benazepril, and Enalapril, where its defined (R)-chirality is crucial for achieving the desired pharmacological activity. Beyond ACE inhibitors, this versatile chiral synthon is used to prepare benzothiophene, benzofuran, and indole derivatives for research into insulin resistance, hyperglycemia, and metabolic disorders. Xinchem offers this pharmaceutical intermediate with flexible custom synthesis, custom chemical synthesis, and reliable contract manufacturing to support your drug development and commercial production. Contact us for a competitive quote and dependable global supply.
